PMID- 21555875
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20220409
IS  - 1421-9670 (Electronic)
IS  - 0250-8095 (Print)
IS  - 0250-8095 (Linking)
VI  - 33
IP  - 6
DP  - 2011
TI  - Impact of fatigue on outcomes in the hemodialysis (HEMO) study.
PG  - 515-23
LID - 10.1159/000328004 [doi]
AB  - BACKGROUND: Fatigue is a common debilitating symptom in chronic kidney disease 
      patients on maintenance hemodialysis. However, little is known about its 
      pathogenesis and association with survival. METHODS: This study examines the 
      correlates and outcomes of fatigue among 1,798 hemodialysis patients enrolled in 
      the HEMO study. Fatigue was assessed using the SF-36 vitality scale. 
      Multivariable analysis was used to assess independent associations of demographic 
      and clinical characteristics with baseline fatigue and longitudinal changes in 
      fatigue. The association of fatigue with all-cause and cause-specific mortality 
      and cardiac hospitalizations was also assessed. RESULTS: Higher index of 
      coexistent diseases (ICED) score, diabetes, non-African-American race, lower 
      serum albumin, use of medications for sleep and poor sleep quality were found to 
      be significantly associated with more fatigue at baseline. In longitudinal 
      analyses, patients who were older, had been on dialysis longer, had higher ICED 
      score, and reported using medications for sleep were more likely to experience 
      worsening fatigue, whereas higher serum albumin was strongly associated with an 
      improvement in level of fatigue. A 10-point increase in vitality score was 
      associated with 10% increase in mean survival (p < 0.0001). CONCLUSIONS: 
      Demographic and clinical factors have significant associations with fatigue, 
      which itself predicts mortality. Improving fatigue in the end-stage renal disease 
      population may positively impact patient well-being and survival.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Jhamb, Manisha
AU  - Jhamb M
AD  - Renal-Electrolyte Division, University of Pittsburgh Medical Center, PA, USA.
FAU - Pike, Francis
AU  - Pike F
FAU - Ramer, Sarah
AU  - Ramer S
FAU - Argyropoulos, Christos
AU  - Argyropoulos C
FAU - Steel, Jennifer
AU  - Steel J
FAU - Dew, Mary Amanda
AU  - Dew MA
FAU - Weisbord, Steven D
AU  - Weisbord SD
FAU - Weissfeld, Lisa
AU  - Weissfeld L
FAU - Unruh, Mark
AU  - Unruh M
LA  - eng
GR  - R01 DK077785/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
DEP - 20110509
PL  - Switzerland
TA  - Am J Nephrol
JT  - American journal of nephrology
JID - 8109361
SB  - IM
MH  - Adult
MH  - Aged
MH  - Fatigue/etiology/*mortality
MH  - Humans
MH  - Kidney Failure, Chronic/complications/*mortality/therapy
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Quality of Life
MH  - Randomized Controlled Trials as Topic
MH  - Renal Dialysis/*mortality
MH  - United States/epidemiology
PMC - PMC4484241
EDAT- 2011/05/11 06:00
MHDA- 2011/10/28 06:00
PMCR- 2012/06/01
CRDT- 2011/05/11 06:00
PHST- 2011/02/17 00:00 [received]
PHST- 2011/03/31 00:00 [accepted]
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
PHST- 2012/06/01 00:00 [pmc-release]
AID - 000328004 [pii]
AID - ajn-0033-0515 [pii]
AID - 10.1159/000328004 [doi]
PST - ppublish
SO  - Am J Nephrol. 2011;33(6):515-23. doi: 10.1159/000328004. Epub 2011 May 9.