PMID- 21555940
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20151119
IS  - 1473-5830 (Electronic)
IS  - 0954-6928 (Linking)
VI  - 22
IP  - 5
DP  - 2011 Aug
TI  - Biomarker profiles as descriptors of left ventricular remodeling after acute 
      myocardial infarction.
PG  - 311-6
LID - 10.1097/MCA.0b013e328346b88d [doi]
AB  - BACKGROUND: Biomarker expression can predict subsequent cardiovascular events. 
      The goal of this study was to determine the pattern of expression in blood of a 
      broad array of cytokines and growth factors taken 24-72 h after an ST elevation 
      myocardial infarction (STEMI) involving the left anterior descending (LAD) 
      coronary artery. METHODS: Blood was taken from 16 patients with LAD STEMI. 
      Cytokine and growth factor expressions were quantified with the use of a 
      Milliplex cytokine/chemokine array analysis that tested 42 analytes. Results from 
      patients were compared with those in blood from 20 healthy volunteers. RESULTS: 
      Most (15/16) participants had positive remodeling without reduction in left 
      ventricular function during follow-up. Analytes were grouped based on their 
      function into those that activate class 1 T-helper cells (Th1 activates 
      cell-mediated immunity), those that activated a Th2 response (activates humoral 
      immunity and attenuates cell-mediated immunity), chemokines (attract leukocytes), 
      and growth factors (promote a healing response). Elevation of cytokines involved 
      in the Th2 response predominated over the Th1 response demonstrating a balance 
      favoring tolerance and limiting activation of cell-mediated immunity. The 
      concentration of selected chemokines favoring cell-mediated immunity was not 
      elevated. The concentration of selected growth factors was increased. CONCLUSION: 
      The cytokine expression, 24-72 h after an LAD STEMI, suggests that positive 
      ventricular remodeling is associated with growth factor expression and limitation 
      of cell-mediated immunity. Subsequent studies are warranted to determine whether 
      deviation from this pattern identifies patients at an increased risk of adverse 
      remodeling after myocardial infarction.
FAU - Lam, Phillip H
AU  - Lam PH
AD  - Cardiology Division, Department of Medicine, University of Vermont, Burlington, 
      USA.
FAU - Anderson, Phillip R 3rd
AU  - Anderson PR 3rd
FAU - Ahmed, Bina
AU  - Ahmed B
FAU - Sobel, Burton E
AU  - Sobel BE
FAU - Vanburen, Peter
AU  - Vanburen P
FAU - Schneider, David J
AU  - Schneider DJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Coron Artery Dis
JT  - Coronary artery disease
JID - 9011445
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/*blood
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Immunity, Cellular
MH  - Intercellular Signaling Peptides and Proteins/*blood
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood
MH  - Pilot Projects
MH  - Th1-Th2 Balance
MH  - Ventricular Remodeling/*physiology
EDAT- 2011/05/11 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 10.1097/MCA.0b013e328346b88d [doi]
PST - ppublish
SO  - Coron Artery Dis. 2011 Aug;22(5):311-6. doi: 10.1097/MCA.0b013e328346b88d.