PMID- 21556651
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20190606
IS  - 1019-6439 (Print)
IS  - 1019-6439 (Linking)
VI  - 6
IP  - 6
DP  - 1995 Jun
TI  - Both dietary calorie and fat affect the growth of transplanted mammary-tumors in 
      riii/sa mice - the effect of calorie is more profound than the effect of fat.
PG  - 1149-57
AB  - The effects of dietary calories and/or fat on the growth of mammary tumor 
      transplants, their expression of mouse mammary tumor virus (MMTV) and the 
      incidence of lung metastasis were examined in RIII/Sa mice. Starting at 3-4 weeks 
      of age, groups of female mice were fed either high isocaloric diets (16 
      kcal/day/mouse) containing 25% or 5% corn or fish oil or low isocaloric (10 
      kcal/day/mouse) diets containing 25% or 5% fish or corn oil. After one week, 
      small pieces (2x2x2 mm) of tumor tissue, prepared from a transplantable mammary 
      tumor, were inserted into the fourth pair of mammary glands of mice, and the mice 
      maintained on their respective diets until sacrifice. All mice developed palpable 
      tumors during a period of 3-4 weeks. After 12 weeks, all those mice that were 
      assessed for tumor burden were sacrificed, tumor weight in each mouse determined, 
      and the level of the expression of MMTV in the tumors evaluated by dot blot 
      hybridization. Our results show that low isocalorie diets, regardless of the type 
      or amount of fat, inhibited tumor growth by at least 60% in comparison to high 
      isocalorie diets. However, mice fed low isocaloric diets containing fish oil were 
      also found to produce smaller tumors (20-40%) as opposed to those mice fed 
      similar, but corn oil containing diets. Fatty acid analyses of mammary tumors and 
      liver tissue of mice fed corn oil and fish oil containing diets revealed that 
      while normal and tumor tissues from both groups contained high levels of 
      polyunsaturated fatty acids, the tissues of mice fed corn oil had the n-6, 
      whereas the mice fed fish oil had the n-3 family of fatty acids. The levels of 
      MMTV expression were found to be unaffected by either caloric or fat content in 
      the diet. In a separate set of experiments, the effect of a low calorie diet on 
      lung metastasis was determined, It was found that mice fed a low calorie diet 
      produced significantly less metastatic lung nodules than those mice fed a high 
      calorie diet: the mean survival time for the former group of mice was 106 days, 
      as compared to only 71 days for the latter group of mice. In conclusion, we 
      suggest that the amount of calories in a diet is more important than the amount 
      or the type of fat in suppressing the growth of transplanted tumors and that a 
      low calorie diet may also lower the incidence of lung metastasis.
FAU - Sarkar, N
AU  - Sarkar N
AD  - AMER HLTH FDN,NAYLOR DANA INST DIS PREVENT,DIV NUTR CARCINOGENESIS,VALHALLA,NY 
      10595.
FAU - Reddy, B
AU  - Reddy B
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Int J Oncol
JT  - International journal of oncology
JID - 9306042
EDAT- 1995/06/01 00:00
MHDA- 1995/06/01 00:01
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 1995/06/01 00:00 [pubmed]
PHST- 1995/06/01 00:01 [medline]
AID - 10.3892/ijo.6.6.1149 [doi]
PST - ppublish
SO  - Int J Oncol. 1995 Jun;6(6):1149-57. doi: 10.3892/ijo.6.6.1149.