PMID- 21556804
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20211020
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 218
IP  - 2
DP  - 2011 Nov
TI  - Intermittent ethanol exposure increases long-lasting behavioral and neurochemical 
      effects of MDMA in adolescent mice.
PG  - 429-42
LID - 10.1007/s00213-011-2329-x [doi]
AB  - RATIONALE: Heavy binge drinking is increasingly frequent among adolescents, while 
      ethanol (EtOH) is often used in combination with 
      3,4-methylenedioxymethamphetamine (MDMA). OBJECTIVES: The long-lasting effects of 
      intermittent exposure to EtOH and MDMA during adolescence on motor activity, 
      anxiety, and social behavior were evaluated in adult mice. The concentration of 
      brain monoamines in the striatum, cortex, and hippocampus was measured following 
      the behavioral test. METHODS: Adolescent OF1 mice were exposed to ethanol (1.25 
      g/kg) on two consecutive days at 48-h intervals over a 14-day period (from PND 29 
      to 42). A total of eight injections of MDMA (10 or 20 mg/kg) were administered 
      twice daily at 4-h intervals over two consecutive days, and this schedule was 
      repeated 6 days later (PND 33, 34, 41, and 42). Behavioral tests and analysis of 
      brain monoamines took place on PND 64 to 67. RESULTS: Exposure to MDMA during 
      adolescence increased the anxiogenic response in the elevated plus maze, with 
      adult mice spending less time in the open arms of the maze and exhibiting lower 
      concentrations of DA in the striatum. A pattern of ethanol administration 
      modeling binge drinking during adolescence enhanced these effects and undermined 
      the hyperthermic response induced by MDMA. Passive avoidance was affected only 
      when EtOH was administered alone. CONCLUSIONS: Juvenile administration of MDMA 
      and alcohol was found to cause a decrease in monoamine levels in adulthood, as 
      well as changes in social interaction behaviors, locomotor activity, increase 
      measures of anxiety in the elevated plus maze (EPM), and decrease step-through 
      latencies in passive avoidance test.
FAU - Rodriguez-Arias, Marta
AU  - Rodriguez-Arias M
AD  - Unidad de Investigacion Psicobiologia de las Drogodependencias, Departamento de 
      Psicobiologia, Facultad de Psicologia, Universitat de Valencia, Avda. Blasco 
      Ibanez 21, 46010 Valencia, Spain. marta.rodriguez@uv.es
FAU - Maldonado, Concepcion
AU  - Maldonado C
FAU - Vidal-Infer, Antonio
AU  - Vidal-Infer A
FAU - Guerri, Consuelo
AU  - Guerri C
FAU - Aguilar, Maria A
AU  - Aguilar MA
FAU - Minarro, Jose
AU  - Minarro J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110510
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Hallucinogens)
RN  - 3K9958V90M (Ethanol)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Anxiety/etiology
MH  - Behavior, Animal/*drug effects
MH  - Brain/drug effects/metabolism
MH  - Dopamine/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Ethanol/administration & dosage/*toxicity
MH  - Hallucinogens/administration & dosage/*toxicity
MH  - Male
MH  - Maze Learning/drug effects
MH  - Mice
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*toxicity
MH  - Social Behavior
EDAT- 2011/05/11 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/05/11 06:00
PHST- 2010/07/01 00:00 [received]
PHST- 2011/04/24 00:00 [accepted]
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - 10.1007/s00213-011-2329-x [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2011 Nov;218(2):429-42. doi: 
      10.1007/s00213-011-2329-x. Epub 2011 May 10.