PMID- 21557149
OWN - NLM
STAT- MEDLINE
DCOM- 20111003
LR  - 20181201
IS  - 1439-4286 (Electronic)
IS  - 0018-5043 (Linking)
VI  - 43
IP  - 6
DP  - 2011 Jun
TI  - Involvement of nitric oxide in corticosterone release and glucose metabolism in 
      food deprived rats.
PG  - 369-73
LID - 10.1055/s-0031-1277155 [doi]
AB  - This study was performed to investigate the involvement of nitric oxide (NO) in 
      corticosterone, endpoint product of hypothalamo-pituitary-adrenal (HPA) axis 
      activation, and metabolic responses to 3 days of food deprivation. To investigate 
      this aim, we used a nonspecific inhibitor of nitric oxide synthases, N-nitro- 
      L-arginine methyl ester (L-NAME). In food deprived group we have noted a 
      significant increase in plasma corticosterone concentration accompanied by a 
      significant depletion in hepatic glycogen content with concomitant increase in 
      glycogen phosphorylase (GP) activity by 63.72%, key enzyme of glycogenolysis and 
      decrease in hexokinase (HK) activity by 25.16%, leading to significant decrease 
      in glucose concentration. However, L-NAME administration in food deprived rats 
      decreased slightly corticosterone level and GP activity (16.39%) and increased HK 
      activity (11.26%) as compared to food deprived group. Considering these results, 
      we can deduce that in food deprivation nitric oxide is involved in the regulation 
      of corticosterone release and in glucose metabolic responses via glycogenolysis 
      activation by the stimulation of GP activity and the inhibition of HK activity. 
      However, more studies are necessary to further clarify the mechanisms by which NO 
      induces these responses.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Mornagui, B
AU  - Mornagui B
AD  - Laboratoire de Physiologie des Agressions, Faculte des Sciences de Tunis, El 
      Manar, Tunisia. bessem.mornagui@fst.rnu.tn
FAU - Rezg, R
AU  - Rezg R
FAU - Grissa, A
AU  - Grissa A
FAU - Gharib, C
AU  - Gharib C
FAU - Kamoun, A
AU  - Kamoun A
FAU - El-Fazaa, S
AU  - El-Fazaa S
FAU - Gharbi, N
AU  - Gharbi N
LA  - eng
PT  - Journal Article
DEP - 20110509
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Blood Glucose)
RN  - 0 (Nitrates)
RN  - 0 (Nitrites)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 9005-79-2 (Glycogen)
RN  - EC 2.4.1.- (Glycogen Phosphorylase)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Blood Glucose/*metabolism
MH  - Body Weight/drug effects
MH  - Corticosterone/blood/*metabolism
MH  - Food Deprivation/*physiology
MH  - Glycogen/metabolism
MH  - Glycogen Phosphorylase/metabolism
MH  - Hexokinase/metabolism
MH  - Liver/drug effects/enzymology
MH  - Male
MH  - NG-Nitroarginine Methyl Ester/administration & dosage/pharmacology
MH  - Nitrates/blood
MH  - Nitric Oxide/*metabolism
MH  - Nitrites/blood
MH  - Rats
MH  - Rats, Wistar
EDAT- 2011/05/11 06:00
MHDA- 2011/10/04 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/10/04 06:00 [medline]
AID - 10.1055/s-0031-1277155 [doi]
PST - ppublish
SO  - Horm Metab Res. 2011 Jun;43(6):369-73. doi: 10.1055/s-0031-1277155. Epub 2011 May 
      9.