PMID- 21558067
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20181201
IS  - 1471-6771 (Electronic)
IS  - 0007-0912 (Linking)
VI  - 106
IP  - 6
DP  - 2011 Jun
TI  - Single-dose intravenous paracetamol or propacetamol for prevention or treatment 
      of postoperative pain: a systematic review and meta-analysis.
PG  - 764-75
LID - 10.1093/bja/aer107 [doi]
AB  - Paracetamol is the most commonly prescribed analgesic for the treatment of acute 
      pain. The efficacy and safety of i.v. formulations of paracetamol is unclear. We 
      performed a systematic search (multiple databases, bibliographies, any language, 
      to May 2010) for single-dose, randomized, controlled clinical trials of 
      propacetamol or i.v. paracetamol for acute postoperative pain in adults or 
      children. Thirty-six studies involving 3896 patients were included. For the 
      primary outcome, 37% of patients (240/367) receiving propacetamol or i.v. 
      paracetamol experienced at least 50% pain relief over 4 h compared with 16% 
      (68/527) receiving placebo (number needed to treat=4.0; 95% confidence interval, 
      3.5-4.8). The proportion of patients in propacetamol or i.v. paracetamol groups 
      experiencing at least 50% pain relief diminished over 6 h. Patients receiving 
      propacetamol or paracetamol required 30% less opioid over 4 h and 16% less opioid 
      over 6 h than those receiving placebo. However, this did not translate to a 
      reduction in opioid-induced adverse events (AEs). Similar comparisons between 
      propacetamol or i.v. paracetamol and active comparators were either not 
      statistically significant, not clinically significant, or both. AEs occurred at 
      similar rates with propacetamol or i.v. paracetamol and placebo. However, pain on 
      infusion occurred more frequently in those receiving propacetamol compared with 
      placebo (23% vs 1%). A single dose of either propacetamol or i.v. paracetamol 
      provides around 4 h of effective analgesia for about 37% of patients with acute 
      postoperative pain. Both formulations are associated with few AEs, although 
      patients receiving propacetamol have a higher incidence of pain on infusion.
FAU - McNicol, E D
AU  - McNicol ED
AD  - Department of Pharmacy and 2 Department of Anesthesiology, Tufts Medical Center, 
      800 Washington Street, Box 420, Boston, MA 02129,USA.
FAU - Tzortzopoulou, A
AU  - Tzortzopoulou A
FAU - Cepeda, M S
AU  - Cepeda MS
FAU - Francia, M B D
AU  - Francia MB
FAU - Farhat, T
AU  - Farhat T
FAU - Schumann, R
AU  - Schumann R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20110509
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 362O9ITL9D (Acetaminophen)
RN  - 5CHW4JMR82 (propacetamol)
SB  - IM
CIN - Br J Anaesth. 2011 Oct;107(4):638; author reply 638-9. PMID: 21903646
MH  - Acetaminophen/*administration & dosage/adverse effects/*analogs & derivatives
MH  - Adult
MH  - Analgesics, Non-Narcotic/*administration & dosage/adverse effects
MH  - Child
MH  - Drug Administration Schedule
MH  - Humans
MH  - Injections, Intravenous
MH  - Pain, Postoperative/drug therapy/*prevention & control
MH  - Randomized Controlled Trials as Topic
EDAT- 2011/05/12 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - S0007-0912(17)33173-2 [pii]
AID - 10.1093/bja/aer107 [doi]
PST - ppublish
SO  - Br J Anaesth. 2011 Jun;106(6):764-75. doi: 10.1093/bja/aer107. Epub 2011 May 9.