PMID- 2155837
OWN - NLM
STAT- MEDLINE
DCOM- 19900419
LR  - 20190813
IS  - 0303-7207 (Print)
IS  - 0303-7207 (Linking)
VI  - 68
IP  - 2-3
DP  - 1990 Jan 22
TI  - Thyroid hormone effects on the proton permeability of rat liver mitochondria.
PG  - 137-41
AB  - The effect of thyroid status on passive permeability of liver mitochondrial inner 
      membrane was studied in euthyroid (EU), hyperthyroid (HYPER), hypothyroid (HYPO) 
      rats and hypothyroid rats treated with a single dose of 3,3',5-triiodothyronine 
      (HYPO + T3). Respiration was titrated with uncoupler and plotted against 
      uncoupler concentration to calculate proton permeability. The passive 
      permeability was the same in EU, HYPER, and HYPO + T3 rats, but was significantly 
      lower in HYPO mitochondria. The State IV respiration rates were the same as the 
      oligomycin-inhibited rats for EU, HYPO and HYPO + T3 rats, but in HYPER rats the 
      oligomycin rate was less than the State IV rate. The data show that hypothyroid 
      mitochondria have decreased permeability of the inner membrane which can be 
      normalized by a single dose of T3. Hyperthyroid mitochondria show increased 
      oligomycin-sensitive ATPase activity in State IV, a possible mechanism of the 
      enhanced respiratory rate.
FAU - Horrum, M A
AU  - Horrum MA
AD  - Department of Internal Medicine, College of Medicine, University of Nebraska 
      Medical Center and Research Service, Omaha.
FAU - Tobin, R B
AU  - Tobin RB
FAU - Ecklund, R E
AU  - Ecklund RE
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (Protons)
RN  - 0 (Thyroid Hormones)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 370-86-5 (Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone)
SB  - IM
MH  - Animals
MH  - Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone/pharmacology
MH  - Hyperthyroidism/metabolism
MH  - Hypothyroidism/metabolism
MH  - In Vitro Techniques
MH  - Intracellular Membranes/metabolism
MH  - Male
MH  - Mitochondria, Liver/drug effects/*metabolism
MH  - Oxygen Consumption/drug effects
MH  - Permeability
MH  - Protons
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Thyroid Hormones/*metabolism
MH  - Triiodothyronine/pharmacology
EDAT- 1990/01/22 00:00
MHDA- 1990/01/22 00:01
CRDT- 1990/01/22 00:00
PHST- 1990/01/22 00:00 [pubmed]
PHST- 1990/01/22 00:01 [medline]
PHST- 1990/01/22 00:00 [entrez]
AID - 0303-7207(90)90186-C [pii]
AID - 10.1016/0303-7207(90)90186-c [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 1990 Jan 22;68(2-3):137-41. doi: 
      10.1016/0303-7207(90)90186-c.