PMID- 21558422
OWN - NLM
STAT- MEDLINE
DCOM- 20120210
LR  - 20191210
IS  - 1531-2267 (Electronic)
IS  - 1094-8341 (Linking)
VI  - 43
IP  - 13
DP  - 2011 Jul 14
TI  - Evolution of the epithelial sodium channel and the sodium pump as limiting 
      factors of aldosterone action on sodium transport.
PG  - 844-54
LID - 10.1152/physiolgenomics.00002.2011 [doi]
AB  - Despite large changes in salt intake, the mammalian kidney is able to maintain 
      the extracellular sodium concentration and osmolarity within very narrow margins, 
      thereby controlling blood volume and blood pressure. In the aldosterone-sensitive 
      distal nephron (ASDN), aldosterone tightly controls the activities of epithelial 
      sodium channel (ENaC) and Na,K-ATPase, the two limiting factors in establishing 
      transepithelial sodium transport. It has been proposed that the ENaC/degenerin 
      gene family is restricted to Metazoans, whereas the alpha- and beta-subunits of 
      Na,K-ATPase have homologous genes in prokaryotes. This raises the question of the 
      emergence of osmolarity control. By exploring recent genomic data of diverse 
      organisms, we found that: 1) ENaC/degenerin exists in all of the Metazoans 
      screened, including nonbilaterians and, by extension, was already present in 
      ancestors of Metazoa; 2) ENaC/degenerin is also present in Naegleria gruberi, an 
      eukaryotic microbe, consistent with either a vertical inheritance from the last 
      common ancestor of Eukaryotes or a lateral transfer between Naegleria and 
      Metazoan ancestors; and 3) The Na,K-ATPase beta-subunit is restricted to Holozoa, 
      the taxon that includes animals and their closest single-cell relatives. Since 
      the beta-subunit of Na,K-ATPase plays a key role in targeting the alpha-subunit to the 
      plasma membrane and has an additional function in the formation of cell 
      junctions, we propose that the emergence of Na,K-ATPase, together with 
      ENaC/degenerin, is linked to the development of multicellularity in the Metazoan 
      kingdom. The establishment of multicellularity and the associated extracellular 
      compartment ("internal milieu") precedes the emergence of other key elements of 
      the aldosterone signaling pathway.
FAU - Studer, Romain A
AU  - Studer RA
AD  - Department of Ecology and Evolution, Biophore, Lausanne, Switzerland. 
      romain.studer@unil.ch
FAU - Person, Emilie
AU  - Person E
FAU - Robinson-Rechavi, Marc
AU  - Robinson-Rechavi M
FAU - Rossier, Bernard C
AU  - Rossier BC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110510
PL  - United States
TA  - Physiol Genomics
JT  - Physiological genomics
JID - 9815683
RN  - 0 (ASIC2 protein, human)
RN  - 0 (Acid Sensing Ion Channels)
RN  - 0 (Degenerin Sodium Channels)
RN  - 0 (Epithelial Sodium Channels)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Phosphoproteins)
RN  - 135541-82-1 (phospholemman)
RN  - 4964P6T9RB (Aldosterone)
RN  - 9NEZ333N27 (Sodium)
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
SB  - IM
MH  - Acid Sensing Ion Channels
MH  - Aldosterone/*metabolism
MH  - Animals
MH  - Degenerin Sodium Channels
MH  - Epithelial Sodium Channels/*genetics
MH  - *Evolution, Molecular
MH  - Humans
MH  - Ion Transport/drug effects
MH  - Membrane Proteins/genetics
MH  - Nerve Tissue Proteins/genetics
MH  - Phosphoproteins/genetics
MH  - Phylogeny
MH  - Sodium/*metabolism
MH  - Sodium-Potassium-Exchanging ATPase/*genetics
EDAT- 2011/05/12 06:00
MHDA- 2012/02/11 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2012/02/11 06:00 [medline]
AID - physiolgenomics.00002.2011 [pii]
AID - 10.1152/physiolgenomics.00002.2011 [doi]
PST - ppublish
SO  - Physiol Genomics. 2011 Jul 14;43(13):844-54. doi: 
      10.1152/physiolgenomics.00002.2011. Epub 2011 May 10.