PMID- 2155875
OWN - NLM
STAT- MEDLINE
DCOM- 19900426
LR  - 20190828
IS  - 0300-8126 (Print)
IS  - 0300-8126 (Linking)
VI  - 18
IP  - 1
DP  - 1990 Jan-Feb
TI  - Prevalence of antibodies to human herpesvirus 6 in different age groups, in 
      children with exanthema subitum, other acute exanthematous childhood diseases, 
      Kawasaki syndrome, and acute infections with other herpesviruses and HIV.
PG  - 12-5
AB  - We determined IgG antibodies against Human Herpesvirus-6 (strain Uganda 1102, M. 
      D. Griffin, London) in the indirect immunofluorescence test in sera from 1105 
      persons of various age groups. Of these sera 570 were retested using HHV-6 strain 
      St. W. (Prof. Schneweis, Bonn). We could confirm that maternal antibodies 
      decrease between birth and six months of age and the seropositive rate rises 
      rapidly between seven months and five years of age up to 79.5%. Between six and 
      ten years and up to 40 years, the antibody-positive rate lies around 81.3% and 
      66%, respectively. To confirm the causal nature of human herpes virus type 6 
      (HHV-6) for exanthema subitum we could demonstrate eight seroconversions testing 
      sera from 14 patients with roseola infantum. In addition, the virus was isolated 
      from peripheral blood lymphocytes of children during the acute fever phase in 
      four cases in tissue culture and in six cases the virus was detected by positive 
      hybridization. In single and some paired sera from patients with acute 
      exanthematous diseases, rubella (n = 28), parvovirus B 19 (n = 24), measles (n = 
      17), mumps (n = 27), adenovirus (n = 27) and parinfluenza virus type 3 (n = 28) 
      and in sera from patients with Kawasaki syndrome (n = 20), acute 
      varicella-zoster- (n = 27), acute herpes simplex- (n = 18) and HIV-1 infection (n 
      = 50), we found no HHV-6 IgM antibodies and no HHV-6 IgG antibody rises. We could 
      only demonstrate an HHV-6 seropositive rate according to our age-prevalence 
      study.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Enders, G
AU  - Enders G
AD  - Inst. f. med. Virologie u. Infektions-epidemiologie, Stuttgart, FR Germany.
FAU - Biber, M
AU  - Biber M
FAU - Meyer, G
AU  - Meyer G
FAU - Helftenbein, E
AU  - Helftenbein E
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Infection
JT  - Infection
JID - 0365307
RN  - 0 (Antibodies, Viral)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Antibodies, Viral/*analysis
MH  - Child
MH  - Child, Preschool
MH  - Exanthema Subitum/epidemiology/*microbiology
MH  - Female
MH  - HIV Infections/epidemiology/microbiology
MH  - Herpesviridae Infections/epidemiology/*microbiology
MH  - Herpesvirus 6, Human/*immunology
MH  - Humans
MH  - Immunoglobulin G/*analysis
MH  - Immunoglobulin M/*analysis
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/epidemiology/microbiology
MH  - Prevalence
MH  - Seroepidemiologic Studies
MH  - Virus Diseases/epidemiology/microbiology
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.1007/BF01644173 [doi]
PST - ppublish
SO  - Infection. 1990 Jan-Feb;18(1):12-5. doi: 10.1007/BF01644173.