PMID- 21559045 OWN - NLM STAT- MEDLINE DCOM- 20111215 LR - 20161125 IS - 1476-5640 (Electronic) IS - 0954-3007 (Linking) VI - 65 IP - 8 DP - 2011 Aug TI - Higher adherence to French dietary guidelines and chronic diseases in the prospective SU.VI.MAX cohort. PG - 887-94 LID - 10.1038/ejcn.2011.61 [doi] AB - BACKGROUND/OBJECTIVES: Nutritional recommendations are widely disseminated, but assessment of their predictive value for risk of chronic diseases and mortality is essential for ensuring their validity. We evaluated, in a large population-based study, the association between the French Programme National Nutrition Sante (PNNS) Guideline Score (GS) (maximum score of 15 points), an a priori-based score, and the incidences of cancer, cardiovascular disease (CVD) and overall mortality. SUBJECTS/METHODS: Subjects included in this analysis (n=5823) were participants in the Supplementation en Vitamines et Mineraux AntioXydants study, with available data for estimating the PNNS-GS. Hazards ratios (HRs) and 95% confidence intervals (95% CIs) for outcomes (cancer, CVD and death) were estimated across quartiles of PNNS-GS using Cox proportional hazards models. RESULTS: A total of 734 major events were recorded during an average 11.6-year follow-up (maximum 13 years): 423 cancers, 193 ischemic diseases and 118 deaths. In the fully adjusted model, a significant reduction in CVD risk between the first and fourth PNNS-GS quartiles (HR=0.65, 95% CI=0.41, 1.00, P for trend=0.04) was observed. No significant overall association with risk of cancer or death was detected. CONCLUSIONS: These observations support the role of nutritional guidelines in prevention of CVD. FAU - Kesse-Guyot, E AU - Kesse-Guyot E AD - UREN, U557 INSERM/U1125 INRA/CNAM/Paris 13 Universite, CRNH IdF, Bobigny, France. e.kesse@uren.smbh.univ-paris13.fr FAU - Touvier, M AU - Touvier M FAU - Henegar, A AU - Henegar A FAU - Czernichow, S AU - Czernichow S FAU - Galan, P AU - Galan P FAU - Hercberg, S AU - Hercberg S FAU - Castetbon, K AU - Castetbon K LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20110511 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 SB - IM MH - Adult MH - Cardiovascular Diseases/epidemiology/prevention & control MH - Chronic Disease MH - Diet/*standards MH - Double-Blind Method MH - *Feeding Behavior MH - Female MH - Follow-Up Studies MH - Guidelines as Topic MH - Humans MH - Life Style MH - Male MH - Middle Aged MH - *Patient Compliance MH - Predictive Value of Tests MH - Prospective Studies MH - Randomized Controlled Trials as Topic MH - Surveys and Questionnaires EDAT- 2011/05/12 06:00 MHDA- 2011/12/16 06:00 CRDT- 2011/05/12 06:00 PHST- 2011/05/12 06:00 [entrez] PHST- 2011/05/12 06:00 [pubmed] PHST- 2011/12/16 06:00 [medline] AID - ejcn201161 [pii] AID - 10.1038/ejcn.2011.61 [doi] PST - ppublish SO - Eur J Clin Nutr. 2011 Aug;65(8):887-94. doi: 10.1038/ejcn.2011.61. Epub 2011 May 11.