PMID- 2156215
OWN - NLM
STAT- MEDLINE
DCOM- 19900424
LR  - 20190818
IS  - 0891-3668 (Print)
IS  - 0891-3668 (Linking)
VI  - 9
IP  - 2
DP  - 1990 Feb
TI  - Role of human herpesvirus 6 infection in infants with exanthema subitum.
PG  - 71-4
AB  - Twenty-two infants with exanthema subitum and their mothers were studied for 
      human herpesvirus 6 (HHV-6) infection. HHV-6 was isolated from 13 of the 22 
      infants, in 5 infants by cultivation of their peripheral blood mononuclear cells 
      and in the other 8 infants by cocultivation of their mononuclear cells with those 
      from newborn cord blood. Of the 22 infants 19 showed a 4-fold or greater rise in 
      HHV-6 antibody titers between the acute and convalescent stages of the disease. 
      These findings support the contention that HHV-6 causes exanthema subitum. 
      Attempts at isolation of HHV-6 from the saliva and peripheral blood mononuclear 
      cells of the mothers of 14 of the 22 infants were unsuccessful. Serum samples 
      from 22 mothers were all reactive to HHV-6 antigens, as evidenced by 
      immunofluorescence and radioimmunoprecipitation analyses.
FAU - Yoshiyama, H
AU  - Yoshiyama H
AD  - Department of Pediatrics, Yamaguchi University School of Medicine, Kogushi, 
      Japan.
FAU - Suzuki, E
AU  - Suzuki E
FAU - Yoshida, T
AU  - Yoshida T
FAU - Kajii, T
AU  - Kajii T
FAU - Yamamoto, N
AU  - Yamamoto N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatr Infect Dis J
JT  - The Pediatric infectious disease journal
JID - 8701858
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Antibodies, Viral/analysis
MH  - Exanthema Subitum/*etiology
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - *Herpesviridae Infections/epidemiology/transmission
MH  - Herpesvirus 6, Human/immunology/isolation & purification
MH  - Humans
MH  - Infant
MH  - Male
MH  - Pregnancy
MH  - Prevalence
MH  - Radioimmunoprecipitation Assay
EDAT- 1990/02/01 00:00
MHDA- 1990/02/01 00:01
CRDT- 1990/02/01 00:00
PHST- 1990/02/01 00:00 [pubmed]
PHST- 1990/02/01 00:01 [medline]
PHST- 1990/02/01 00:00 [entrez]
AID - 10.1097/00006454-199002000-00001 [doi]
PST - ppublish
SO  - Pediatr Infect Dis J. 1990 Feb;9(2):71-4. doi: 10.1097/00006454-199002000-00001.