PMID- 21562370
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20131121
IS  - 1535-2811 (Electronic)
IS  - 1535-2811 (Linking)
VI  - 10
IP  - 1
DP  - 2011 Mar
TI  - Outpatient aspirin desensitization for patients with aspirin hypersensitivity and 
      cardiac disease.
PG  - 17-21
LID - 10.1097/HPC.0b013e318213d5a6 [doi]
AB  - BACKGROUND: Cardiac disease is common and often treated with aspirin therapy. 
      Patients who develop an immunoglobulin E (IgE) hypersensitivity reaction to 
      aspirin must abort treatment and receive alternative antithrombotic agents. 
      Aspirin desensitization is a therapeutic procedure that may allow patients with a 
      history of hypersensitivity to safely resume aspirin treatment. A variety of 
      inpatient desensitization protocols have been published for IgE-mediated 
      reactions, but outpatient regimens have not been previously reported. OBJECTIVE: 
      We aimed to determine the efficacy and safety of a multiday outpatient aspirin 
      desensitization protocol for patients with an IgE-mediated aspirin 
      hypersensitivity. METHODS: We retrospectively assessed the efficacy of a 
      multidose aspirin desensitization protocol performed in a university 
      allergy-immunology clinic between July 2006 and December 2009. Patients were 
      referred for a diagnosis of aspirin hypersensitivity and required aspirin for 
      cardiac disease treatment. The protocol involved 10 or 12 aspirin doses depending 
      on the final dose of 81 or 325 mg. Patients were desensitized over 2 to 3 
      half-days and were able to return home in between desensitization sessions. 
      RESULTS: A total of 9 patients with cardiac disease and aspirin hypersensitivity 
      underwent an outpatient multiday aspirin desensitization. Eight patients (89%) 
      were successfully desensitized and 1 patient declined to continue with further 
      desensitization. No adverse reactions requiring inpatient hospital care occurred 
      during desensitization. CONCLUSIONS: This novel outpatient multiday aspirin 
      desensitization protocol was a safe and effective approach for the treatment of 
      aspirin hypersensitivity in patients with cardiac disease who require aspirin 
      therapy. This flexible protocol is convenient for patients by avoiding hospital 
      admission and full-day time commitments.
FAU - Fajt, Merritt L
AU  - Fajt ML
AD  - Division of Pulmonary, Allergy, and Critical Care Medicine, University of 
      Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
FAU - Petrov, Andrej A
AU  - Petrov AA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Crit Pathw Cardiol
JT  - Critical pathways in cardiology
JID - 101165286
RN  - 37341-29-0 (Immunoglobulin E)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aspirin/*administration & dosage/immunology
MH  - Clinical Protocols
MH  - *Desensitization, Immunologic
MH  - Drug Hypersensitivity/*drug therapy/immunology
MH  - Female
MH  - Heart Diseases/*drug therapy/immunology
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Male
MH  - Middle Aged
MH  - Outpatients
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/05/13 06:00
MHDA- 2011/09/14 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
AID - 00132577-201103000-00003 [pii]
AID - 10.1097/HPC.0b013e318213d5a6 [doi]
PST - ppublish
SO  - Crit Pathw Cardiol. 2011 Mar;10(1):17-21. doi: 10.1097/HPC.0b013e318213d5a6.