PMID- 21562420
OWN - NLM
STAT- MEDLINE
DCOM- 20120416
LR  - 20220408
IS  - 1365-2346 (Electronic)
IS  - 0265-0215 (Linking)
VI  - 29
IP  - 1
DP  - 2012 Jan
TI  - Intrathecal hydromorphone added to hyperbaric bupivacaine for postoperative pain 
      relief after knee arthroscopic surgery: a prospective, randomised, controlled 
      trial.
PG  - 17-21
LID - 10.1097/EJA.0b013e3283476055 [doi]
AB  - BACKGROUND AND OBJECTIVE: Adding opioid to spinal anaesthetic provides additional 
      analgesia during the postoperative period. The purpose of this study was to 
      determine the dose of intrathecal hydromorphone necessary to achieve 
      postoperative pain relief after arthroscopic knee surgery. METHODS: In a 
      prospective, double-blinded parallel, placebo-controlled manner, 60 patients who 
      were undergoing unilateral knee arthroscopy randomly received unilateral spinal 
      anaesthesia with 0.5% hyperbaric bupivacaine 6 mg combined with 0.0, 2.5, 5.0 or 
      10.0 mug per 0.05 ml hydromorphone. Fifteen patients were assigned to receive each 
      dose. The visual analogue pain scores (VAPSs) were measured at 30 min and 2, 4, 
      6, 12 and 24 h postoperatively, and the side-effects of hydromorphone were 
      recorded. RESULTS: The postoperative VAPSs at 4, 6 and 12 h for the 5 and 10 mug 
      hydromorphone groups were significantly decreased, compared to the control group. 
      The 2.5 mug hydromorphone group had lower VAPS only at 4 and 6 h postoperatively. 
      Nausea was significantly increased in the 10 mug hydromorphone group (46.6%). 
      CONCLUSION: The analgesic effects of 5 and 10 mug intrathecal hydromorphone 
      provided satisfactory pain relief for 12 h postoperatively and nausea increased 
      significantly in a dose-dependent manner.
FAU - Lee, Yoon-Sook
AU  - Lee YS
AD  - Department of Anesthesiology and Pain Medicine, Korea University Ansan Hospital, 
      Korea University College of Medicine, Ansan City, Kyeongi Province, Korea.
FAU - Park, Young-Cheol
AU  - Park YC
FAU - Kim, Jae-Hwan
AU  - Kim JH
FAU - Kim, Woon-Young
AU  - Kim WY
FAU - Yoon, Seung-Zjoo
AU  - Yoon SZ
FAU - Moon, Man-Gook
AU  - Moon MG
FAU - Min, Too Jae
AU  - Min TJ
LA  - eng
SI  - ClinicalTrials.gov/NCT01172782
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Anaesthesiol
JT  - European journal of anaesthesiology
JID - 8411711
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anesthetics, Local)
RN  - 0 (Placebos)
RN  - Q812464R06 (Hydromorphone)
RN  - Y8335394RO (Bupivacaine)
SB  - IM
CIN - Eur J Anaesthesiol. 2012 Jan;29(1):3-4. PMID: 22127266
MH  - Adult
MH  - Analgesics, Opioid/*administration & dosage/adverse effects
MH  - *Anesthesia, Spinal
MH  - Anesthetics, Local/*administration & dosage
MH  - Arthroscopy/*adverse effects
MH  - Bupivacaine/*administration & dosage
MH  - Chi-Square Distribution
MH  - Double-Blind Method
MH  - Drug Therapy, Combination
MH  - Female
MH  - Humans
MH  - Hydromorphone/*administration & dosage/adverse effects
MH  - Injections, Spinal
MH  - Knee Joint/*surgery
MH  - Male
MH  - Middle Aged
MH  - Pain Measurement
MH  - Pain, Postoperative/diagnosis/etiology/*prevention & control
MH  - Placebos
MH  - Postoperative Nausea and Vomiting/etiology
MH  - Prospective Studies
MH  - Republic of Korea
MH  - Time Factors
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/05/13 06:00
MHDA- 2012/04/17 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2012/04/17 06:00 [medline]
AID - 10.1097/EJA.0b013e3283476055 [doi]
PST - ppublish
SO  - Eur J Anaesthesiol. 2012 Jan;29(1):17-21. doi: 10.1097/EJA.0b013e3283476055.