PMID- 21562627
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1179-1748 (Print)
IS  - 1179-1748 (Electronic)
VI  - 2
DP  - 2010 Mar 23
TI  - Exposure to Persistent Organic Pollutants Increases Hospitalization Rates for 
      Myocardial Infarction with Comorbid Hypertension.
PG  - 1-9
AB  - Studies suggest that environmental exposure to persistent organic pollutants 
      (POPs) may be an emerging risk factor for ischemic heart disease, including acute 
      myocardial infarction (AMI). However, some studies indicate that exposure to POPs 
      may also be a risk factor for hypertension, a well-established risk factor for 
      AMI. To investigate effect of POPs on the environmental burden of cardiovascular 
      disease, a study of AMI with comorbid hypertension in populations environmentally 
      exposed to persistent organic pollutants, based on the zip code of residence, was 
      conducted. Data on hospital discharges for AMI with comorbid hypertension were 
      obtained from the New York Statewide Planning and Research Cooperative System for 
      1993-2004. Patients residing in zip codes containing or abutting POPs 
      contaminated sites were considered environmentally exposed. Relative risks (RR) - 
      with corresponding 95% confidence intervals (95% CI) - of hospitalization for AMI 
      with comorbid hypertension were estimated by Poisson regression, adjusting for 
      known confounders. Adjusted hospitalization rates for AMI with comorbid 
      hypertension were 12.4% higher in populations residing in proximity to a POPs 
      site (adjusted RR = 1.124, 95% CI 1.025-1.233, p < 0.05), compared to not in 
      proximity to a POPs site. Also, hospitalization rates for AMI with comorbid 
      hypertension were higher in males than in females (adjusted RR = 2.157, 95% CI 
      2.100-2.215, p < 0.05), in African Americans than in Caucasians (adjusted RR = 
      1.631, 95% CI 1.483-1.794, p < 0.05), and in older age groups (p for trend 
      <0.05). These findings are consistent with the established effects of 
      non-modifiable risk factors and serve as indirect quality indicators for our 
      model. In conclusion, our results support the hypothesis that environmental 
      exposure to POPs increases the burden of cardiovascular disease in exposed 
      populations.
FAU - Sergeev, Alexander V
AU  - Sergeev AV
AD  - School of Public Health Sciences and Professions, Ohio University, Athens, OH, 
      USA.
FAU - Carpenter, David O
AU  - Carpenter DO
LA  - eng
GR  - D43 TW000636/TW/FIC NIH HHS/United States
GR  - D43 TW000636-08/TW/FIC NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Prim Prev Insights
JT  - Primary prevention insights
JID - 101531636
PMC - PMC3090223
MID - NIHMS190185
COIS- The authors report no conflicts of interest.
EDAT- 2010/03/23 00:00
MHDA- 2010/03/23 00:01
PMCR- 2011/05/09
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2010/03/23 00:00 [pubmed]
PHST- 2010/03/23 00:01 [medline]
PHST- 2011/05/09 00:00 [pmc-release]
AID - 10.4137/PPRI.S4332 [doi]
PST - ppublish
SO  - Prim Prev Insights. 2010 Mar 23;2:1-9. doi: 10.4137/PPRI.S4332.