PMID- 21563234
OWN - NLM
STAT- MEDLINE
DCOM- 20111107
LR  - 20220408
IS  - 1098-2264 (Electronic)
IS  - 1045-2257 (Linking)
VI  - 50
IP  - 8
DP  - 2011 Aug
TI  - 13q14 deletion size and number of deleted cells both influence prognosis in 
      chronic lymphocytic leukemia.
PG  - 633-43
LID - 10.1002/gcc.20885 [doi]
AB  - Deletion at 13q14 is detected by fluorescence in situ hybridization (FISH) in 
      about 50% of chronic lymphocytic leukemia (CLL). Although CLL with 13q deletion 
      as the sole cytogenetic abnormality (del13q-only) usually have good prognosis, 
      more aggressive clinical courses are documented for del13q-only CLL carrying 
      higher percentages of 13q deleted nuclei. Moreover, deletion at 13q of different 
      sizes have been described, whose prognostic significance is still unknown. In a 
      multi-institutional cohort of 342 del13q-only cases and in a consecutive 
      unselected cohort of 265 CLL, we investigated the prognostic significance of 13q 
      deletion, using the 13q FISH probes locus-specific identifier (LSI)-D13S319 and 
      LSI-RB1 that detect the DLEU2/MIR15A/MIR16-1 and RB1 loci, respectively. Results 
      indicated that both percentage of deleted nuclei and presence of larger deletions 
      involving the RB1 locus cooperated to refine the prognosis of del13q-only cases. 
      In particular, CLL carrying <70% of 13q deleted nuclei with deletions not 
      comprising the RB1 locus were characterized by particularly long 
      time-to-treatment. Conversely, CLL with 13q deletion in <70% of nuclei but 
      involving the RB1 locus, or CLL carrying 13q deletion in >/=70% of nuclei, with or 
      without RB1 deletions, collectively experienced shorter time-to-treatment. A 
      revised flowchart for the prognostic FISH assessment of del13q-only CLL, implying 
      the usage of both 13q probes, is proposed.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Dal Bo, Michele
AU  - Dal Bo M
AD  - Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, 
      IRCCS, Aviano (PN), Italy.
FAU - Rossi, Francesca Maria
AU  - Rossi FM
FAU - Rossi, Davide
AU  - Rossi D
FAU - Deambrogi, Clara
AU  - Deambrogi C
FAU - Bertoni, Francesco
AU  - Bertoni F
FAU - Del Giudice, Ilaria
AU  - Del Giudice I
FAU - Palumbo, Giuseppe
AU  - Palumbo G
FAU - Nanni, Mauro
AU  - Nanni M
FAU - Rinaldi, Andrea
AU  - Rinaldi A
FAU - Kwee, Ivo
AU  - Kwee I
FAU - Tissino, Erika
AU  - Tissino E
FAU - Corradini, Giorgia
AU  - Corradini G
FAU - Gozzetti, Alessandro
AU  - Gozzetti A
FAU - Cencini, Emanuele
AU  - Cencini E
FAU - Ladetto, Marco
AU  - Ladetto M
FAU - Coletta, Angela Maria
AU  - Coletta AM
FAU - Luciano, Fabrizio
AU  - Luciano F
FAU - Bulian, Pietro
AU  - Bulian P
FAU - Pozzato, Gabriele
AU  - Pozzato G
FAU - Laurenti, Luca
AU  - Laurenti L
FAU - Forconi, Francesco
AU  - Forconi F
FAU - Di Raimondo, Francesco
AU  - Di Raimondo F
FAU - Marasca, Roberto
AU  - Marasca R
FAU - Del Poeta, Giovanni
AU  - Del Poeta G
FAU - Gaidano, Gianluca
AU  - Gaidano G
FAU - Foa, Robin
AU  - Foa R
FAU - Guarini, Anna
AU  - Guarini A
FAU - Gattei, Valter
AU  - Gattei V
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110511
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (DLEU2 lncRNA, human)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (Retinoblastoma Protein)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.- (Transferases)
RN  - 13q deletion syndrome
SB  - IM
MH  - Chromosome Deletion
MH  - Chromosome Disorders/*genetics
MH  - Chromosomes, Human, Pair 13/genetics
MH  - Cohort Studies
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics/pathology
MH  - Prognosis
MH  - RNA, Long Noncoding
MH  - Retinoblastoma Protein/genetics
MH  - Sequence Deletion
MH  - Transferases
MH  - Tumor Suppressor Proteins/genetics
EDAT- 2011/05/13 06:00
MHDA- 2011/11/08 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/01/13 00:00 [received]
PHST- 2011/03/25 00:00 [revised]
PHST- 2011/03/27 00:00 [accepted]
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2011/11/08 06:00 [medline]
AID - 10.1002/gcc.20885 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 2011 Aug;50(8):633-43. doi: 10.1002/gcc.20885. Epub 
      2011 May 11.