PMID- 2156361
OWN - NLM
STAT- MEDLINE
DCOM- 19900418
LR  - 20211203
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 49
IP  - 3
DP  - 1990 Mar
TI  - Human herpesvirus 6 infection in renal transplantation.
PG  - 519-22
AB  - The relationship between renal transplantation and human herpesvirus 6 (HHV-6) 
      infection was studied. All 21 kidney donors examined had antibody to HHV-6 at the 
      time of transplantation. The 21 kidney recipients also had detectable antibody to 
      HHV-6 before transplantation--and, of these, 8 patients showed a significant 
      increase of serum antibody titer against HHV-6 after transplantation. All these 8 
      recipients suffered severe kidney rejection. Furthermore, virus isolation from 
      peripheral blood lymphocytes of 2 recipients who suffered rejection was 
      attempted, and in both cases HHV-6 was isolated. Biopsy specimens of rejected 
      kidneys of 9 other patients were examined for the presence of HHV-6 antigens, and 
      in 5 of these specimens antigens were detected in the tubular epithelium, as well 
      as in infiltrating histiocytes and lymphocytes. These results suggest that HHV-6 
      can infect renal tissues and that the infection may be correlated with rejection 
      or with immunosuppressive therapy.
FAU - Okuno, T
AU  - Okuno T
AD  - Department of Virology, Osaka University, Japan.
FAU - Higashi, K
AU  - Higashi K
FAU - Shiraki, K
AU  - Shiraki K
FAU - Yamanishi, K
AU  - Yamanishi K
FAU - Takahashi, M
AU  - Takahashi M
FAU - Kokado, Y
AU  - Kokado Y
FAU - Ishibashi, M
AU  - Ishibashi M
FAU - Takahara, S
AU  - Takahara S
FAU - Sonoda, T
AU  - Sonoda T
FAU - Tanaka, K
AU  - Tanaka K
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral)
SB  - IM
MH  - Adult
MH  - Antibodies, Viral/analysis
MH  - Antigens, Viral/analysis
MH  - Graft Rejection
MH  - Herpesviridae Infections/*complications
MH  - Herpesvirus 6, Human/immunology/*pathogenicity
MH  - Histocompatibility
MH  - Humans
MH  - Immunosuppression Therapy/methods
MH  - Kidney/pathology
MH  - *Kidney Transplantation/immunology
MH  - Middle Aged
MH  - Tissue Donors
EDAT- 1990/03/01 00:00
MHDA- 1990/03/01 00:01
CRDT- 1990/03/01 00:00
PHST- 1990/03/01 00:00 [pubmed]
PHST- 1990/03/01 00:01 [medline]
PHST- 1990/03/01 00:00 [entrez]
AID - 10.1097/00007890-199003000-00009 [doi]
PST - ppublish
SO  - Transplantation. 1990 Mar;49(3):519-22. doi: 10.1097/00007890-199003000-00009.