PMID- 21565404
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20190816
IS  - 1873-5835 (Electronic)
IS  - 0145-2126 (Linking)
VI  - 35
IP  - 8
DP  - 2011 Aug
TI  - Increased MLL gene rearrangements in amniocytes from fetuses of mothers who 
      smoke.
PG  - 1066-9
LID - 10.1016/j.leukres.2011.04.010 [doi]
AB  - We assess the possible genotoxic effect of maternal smoking on amniotic fluid 
      cells, based on the presence of an increasing of structural abnormality of the 
      11q23 band bearing the MLL gene rearrangements. In this observational and 
      prospective study cultured amniocytes were obtained from 20 control and 20 women 
      who smoke (>10 cigarettes/day for >10 years and during pregnancy). We performed 
      fluorescence in situ hybridization (FISH) analysis in amniocytes. Comparison of 
      FISH data between smoker and control groups showed statistical significance for 
      the MLL gene rearrangements. Epidemiologic studies, including a large series of 
      patients, will be needed to determine whether the offspring of parents who smoke 
      have an increased lifetime risk of leukemia.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - de la Chica, Rosa Ana
AU  - de la Chica RA
AD  - Laboratori de Citogenetica Molecular, Servei de Patologia, Hospital del Mar, 
      IMAS, Barcelona, Spain. rosaana.delachica@uab.cat
FAU - Mediano, Carmen
AU  - Mediano C
FAU - Salido, Marta
AU  - Salido M
FAU - Espinet, Blanca
AU  - Espinet B
FAU - Manresa, Josep Maria
AU  - Manresa JM
FAU - Sole, Francesc
AU  - Sole F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110511
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
RN  - 0 (KMT2A protein, human)
RN  - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
SB  - IM
MH  - Adult
MH  - Amniotic Fluid/cytology/*metabolism
MH  - Case-Control Studies
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Female
MH  - Fetus/*drug effects
MH  - Gene Rearrangement/*drug effects
MH  - Histone-Lysine N-Methyltransferase
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Mothers
MH  - Myeloid-Lymphoid Leukemia Protein/*genetics
MH  - Pregnancy
MH  - Prognosis
MH  - Prospective Studies
MH  - Smoking/*adverse effects
EDAT- 2011/05/14 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/14 06:00
PHST- 2010/11/22 00:00 [received]
PHST- 2011/03/26 00:00 [revised]
PHST- 2011/04/12 00:00 [accepted]
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S0145-2126(11)00197-4 [pii]
AID - 10.1016/j.leukres.2011.04.010 [doi]
PST - ppublish
SO  - Leuk Res. 2011 Aug;35(8):1066-9. doi: 10.1016/j.leukres.2011.04.010. Epub 2011 
      May 11.