PMID- 21565864
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20181201
IS  - 1460-2407 (Electronic)
IS  - 1360-9947 (Linking)
VI  - 17
IP  - 10
DP  - 2011 Oct
TI  - Human decidua and invasive trophoblasts are rich sources of nearly all human 
      matrix metalloproteinases.
PG  - 637-52
LID - 10.1093/molehr/gar033 [doi]
AB  - Trophoblast cell (CTB) invasion into the maternal endometrium plays a crucial 
      role during human embryo implantation and placentation. As for all invasive cell 
      types, the ability of CTB to infiltrate the uterine wall is facilitated by the 
      activity of matrix metalloproteinases (MMPs), which is regulated by tissue 
      inhibitors of MMPs (TIMPs). There is evidence for the expression of several MMPs 
      and TIMPs in decidua. However, published data are limited. Therefore, to set a 
      foundation for future research, we screened a panel of healthy human deciduas 
      obtained during first, second and third trimester of pregnancy in addition to 
      isolated decidual cell populations for the expression of all known human MMPs and 
      TIMPs by RT-PCR, western blot and immunohistochemistry. In the decidual samples, 
      we detected almost all MMPs and all four TIMPs at mRNA level. While the 
      expression of proMMP-3 and active MMP-13 and -23 was down-regulated in the course 
      of pregnancy, the pro forms of MMP-8, -19 and -23, active MMP-9, -10, -12, -15, 
      -16, -26 and -28, and pro- and active MMP-14 increased towards the end of 
      gestation. All MMPs and TIMPs were expressed in uterine natural killer cells, 
      decidual fibroblasts and/or trophoblasts, with the exception of MMP-20 and -25. 
      In summary, a remarkably broad spectrum of MMPs was expressed at the human 
      feto-maternal interface, reflecting the highly invasive and remodelling effect on 
      placenta formation. It can be speculated that expression of MMPs correlates with 
      the invasive potential of CTBs together with a crucial role in activation of 
      labour at term.
FAU - Anacker, Jelena
AU  - Anacker J
AD  - Department of Obstetrics and Gynaecology, University Hospital of Wurzburg, 
      Germany. stojic_j@klinik.uni-wuerzburg.de
FAU - Segerer, Sabine E
AU  - Segerer SE
FAU - Hagemann, Carsten
AU  - Hagemann C
FAU - Feix, Sonja
AU  - Feix S
FAU - Kapp, Michaela
AU  - Kapp M
FAU - Bausch, Renate
AU  - Bausch R
FAU - Kammerer, Ulrike
AU  - Kammerer U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110512
PL  - England
TA  - Mol Hum Reprod
JT  - Molecular human reproduction
JID - 9513710
RN  - 0 (RNA, Messenger)
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Decidua/cytology/*enzymology/metabolism
MH  - Embryo Implantation
MH  - Female
MH  - Fibroblasts/metabolism
MH  - Humans
MH  - Killer Cells, Natural/metabolism
MH  - Matrix Metalloproteinases/*metabolism
MH  - Placenta/metabolism
MH  - Placentation/physiology
MH  - Pregnancy
MH  - RNA, Messenger/biosynthesis
MH  - Tissue Inhibitor of Metalloproteinases/*metabolism
MH  - Trophoblasts/*enzymology/metabolism
EDAT- 2011/05/14 06:00
MHDA- 2012/01/20 06:00
CRDT- 2011/05/14 06:00
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
AID - gar033 [pii]
AID - 10.1093/molehr/gar033 [doi]
PST - ppublish
SO  - Mol Hum Reprod. 2011 Oct;17(10):637-52. doi: 10.1093/molehr/gar033. Epub 2011 May 
      12.