PMID- 21566870
OWN - NLM
STAT- MEDLINE
DCOM- 20150623
LR  - 20181201
IS  - 1006-7248 (Print)
IS  - 1006-7248 (Linking)
VI  - 20
IP  - 2
DP  - 2011 Apr
TI  - [Detection and clinical significance of MCP-1 in gingival crevicular fluid from 
      patients with chronic periodontitis].
PG  - 183-6
AB  - PURPOSE: To evaluate the concentration of monocyte chemoattractant protein-1 
      (MCP-1) in the gingival crevicular fluid from patients with chronic periodontitis 
      and its correlation with clinic periodontal parameters as well as alkaline 
      phosphates secretions. METHODS: Gingival crevicular fluid (GCF) was collected 
      with standardized filter strips from healthy control sites as well as 
      periodontitis sites from chronic periodontitis patients before and after initial 
      therapy, and the levels of MCP-1 and alkaline phosphatase were detected by ELISA. 
      The data was analyzed with SPSS 11.0 software package. RESULTS: Concentration of 
      MCP-1 in GCF was significantly higher in chronic periodontitis patients, and 
      decreased significantly after initial therapy, the variation of MCP-1 correlated 
      positively with clinical parameters like plaque index(PLI), probing depth (PD), 
      gingival index (GI), clinic attachment lost (CAL) as well as alkaline phosphatase 
      secretion. CONCLUSIONS: As an inflammatory chemotatic factor, MCP-1 in GCF may 
      play an important role in occurrence and development of chronic periodontitis, 
      and could be considered as a potential target for prevention and treatment of 
      chronic periodontitis.
FAU - Zhang, Zun
AU  - Zhang Z
AD  - Department of Stomatology, First People's Hospital, Shanghai Jiao Tong 
      University, Shanghai 200011, China. rainyzhangzun@hotmail.com
FAU - Sun, Qing
AU  - Sun Q
FAU - Wang, Xiao-li
AU  - Wang XL
LA  - chi
PT  - Journal Article
PL  - China
TA  - Shanghai Kou Qiang Yi Xue
JT  - Shanghai kou qiang yi xue = Shanghai journal of stomatology
JID - 101090220
RN  - 0 (Chemokine CCL2)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
SB  - IM
MH  - Alkaline Phosphatase
MH  - Chemokine CCL2
MH  - *Chronic Periodontitis
MH  - Dental Plaque Index
MH  - *Gingival Crevicular Fluid
MH  - Humans
MH  - Periodontal Attachment Loss
MH  - Periodontal Index
MH  - Periodontal Pocket
MH  - Periodontitis
EDAT- 2011/05/14 06:00
MHDA- 2015/06/24 06:00
CRDT- 2011/05/14 06:00
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2015/06/24 06:00 [medline]
PST - ppublish
SO  - Shanghai Kou Qiang Yi Xue. 2011 Apr;20(2):183-6.