PMID- 21567557
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110513
IS  - 1521-3927 (Electronic)
IS  - 1022-1336 (Linking)
VI  - 31
IP  - 17
DP  - 2010 Sep 1
TI  - Synthesis, Characterization and Preliminary Biological Evaluation of 
      P(HPMA)-b-P(LLA) Copolymers: A New Type of Functional Biocompatible Block 
      Copolymer.
PG  - 1492-500
LID - 10.1002/marc.201000090 [doi]
AB  - We describe a synthetic pathway to functional P(HPMA)-b-P(LLA) block copolymers. 
      The synthesis relies on a combination of ring-opening polymerization of 
      L-lactide, conversion into a chain transfer agent (CTA) for the RAFT 
      polymerization of pentafluorophenyl methacrylate. A series of block copolymers 
      was prepared that exhibited molecular weights $\overline M _\rm n$ ranging from 
      7 600 to 34 300 g . mol(-1) , with moderate PDI between 1.3 and 1.45. These 
      reactive precursor polymers have been transformed into biocompatible 
      P(HPMA)-b-P(LLA) copolymers and their fluorescently labeled derivatives by facile 
      replacement of the pentafluorophenyl groups. The fluorescence label attached to 
      this new type of a partially degradable amphiphilic block copolymer was used to 
      study cellular uptake in human cervix adenocarcinoma (HeLa) cells as well as 
      aggregation behavior by fluorescence correlation spectroscopy (FCS).
CI  - Copyright (c) 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Barz, Matthias
AU  - Barz M
AD  - Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 
      10-14, D-55099 Mainz, Germany.
FAU - Wolf, Florian K
AU  - Wolf FK
FAU - Canal, Fabiana
AU  - Canal F
FAU - Koynov, Kaloian
AU  - Koynov K
FAU - Vicent, Maria J
AU  - Vicent MJ
FAU - Frey, Holger
AU  - Frey H
FAU - Zentel, Rudolf
AU  - Zentel R
LA  - eng
PT  - Journal Article
DEP - 20100609
PL  - Germany
TA  - Macromol Rapid Commun
JT  - Macromolecular rapid communications
JID - 9888239
EDAT- 2011/05/14 06:00
MHDA- 2011/05/14 06:01
CRDT- 2011/05/14 06:00
PHST- 2010/02/06 00:00 [received]
PHST- 2010/03/10 00:00 [revised]
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2011/05/14 06:01 [medline]
AID - 10.1002/marc.201000090 [doi]
PST - ppublish
SO  - Macromol Rapid Commun. 2010 Sep 1;31(17):1492-500. doi: 10.1002/marc.201000090. 
      Epub 2010 Jun 9.