PMID- 21568686
OWN - NLM
STAT- MEDLINE
DCOM- 20120823
LR  - 20240412
IS  - 1557-9042 (Electronic)
IS  - 0897-7151 (Print)
IS  - 0897-7151 (Linking)
VI  - 28
IP  - 12
DP  - 2011 Dec
TI  - Role of spared pathways in locomotor recovery after body-weight-supported 
      treadmill training in contused rats.
PG  - 2405-16
LID - 10.1089/neu.2010.1660 [doi]
AB  - Body-weight-supported treadmill training (BWSTT)-related locomotor recovery has 
      been shown in spinalized animals. Only a few animal studies have demonstrated 
      locomotor recovery after BWSTT in an incomplete spinal cord injury (SCI) model, 
      such as contusion injury. The contribution of spared descending pathways after 
      BWSTT to behavioral recovery is unclear. Our goal was to evaluate locomotor 
      recovery in contused rats after BWSTT, and to study the role of spared pathways 
      in spinal plasticity after BWSTT. Forty-eight rats received a contusion, a 
      transection, or a contusion followed at 9 weeks by a second transection injury. 
      Half of the animals in the three injury groups were given BWSTT for up to 8 
      weeks. Kinematics and the Basso-Beattie-Bresnahan (BBB) test assessed behavioral 
      improvements. Changes in Hoffmann-reflex (H-reflex) rate depression property, 
      soleus muscle mass, and sprouting of primary afferent fibers were also evaluated. 
      BWSTT-contused animals showed accelerated locomotor recovery, improved H-reflex 
      properties, reduced muscle atrophy, and decreased sprouting of small caliber 
      afferent fibers. BBB scores were not improved by BWSTT. Untrained contused rats 
      that received a transection exhibited a decrease in kinematic parameters 
      immediately after the transection; in contrast, trained contused rats did not 
      show an immediate decrease in kinematic parameters after transection. This 
      suggests that BWSTT with spared descending pathways leads to neuroplasticity at 
      the lumbar spinal level that is capable of maintaining locomotor activity. 
      Discontinuing training after the transection in the trained contused rats 
      abolished the improved kinematics within 2 weeks and led to a reversal of the 
      improved H-reflex response, increased muscle atrophy, and an increase in primary 
      afferent fiber sprouting. Thus continued training may be required for maintenance 
      of the recovery. Transected animals had no effect of BWSTT, indicating that in 
      the absence of spared pathways this training paradigm did not improve function.
FAU - Singh, Anita
AU  - Singh A
AD  - Department of Neurobiology and Anatomy, Drexel University College of Medicine, 
      Philadelphia, Pennsylvania 19129, USA. anitausingh@hotmail.com
FAU - Balasubramanian, Sriram
AU  - Balasubramanian S
FAU - Murray, Marion
AU  - Murray M
FAU - Lemay, Michel
AU  - Lemay M
FAU - Houle, John
AU  - Houle J
LA  - eng
GR  - NS 055976/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110808
PL  - United States
TA  - J Neurotrauma
JT  - Journal of neurotrauma
JID - 8811626
SB  - IM
MH  - Animals
MH  - Body Weight/physiology
MH  - Contusions/physiopathology/*rehabilitation
MH  - Exercise Test/*methods
MH  - Exercise Therapy/*methods
MH  - Female
MH  - H-Reflex/physiology
MH  - Motor Activity/*physiology
MH  - Muscle, Skeletal/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Recovery of Function/*physiology
MH  - Spinal Cord Injuries/physiopathology/*rehabilitation
PMC - PMC3235344
EDAT- 2011/05/17 06:00
MHDA- 2012/08/24 06:00
PMCR- 2012/12/01
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2012/08/24 06:00 [medline]
PHST- 2012/12/01 00:00 [pmc-release]
AID - 10.1089/neu.2010.1660 [pii]
AID - 10.1089/neu.2010.1660 [doi]
PST - ppublish
SO  - J Neurotrauma. 2011 Dec;28(12):2405-16. doi: 10.1089/neu.2010.1660. Epub 2011 Aug 
      8.