PMID- 21568944
OWN - NLM
STAT- MEDLINE
DCOM- 20120130
LR  - 20131121
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 78
IP  - 3
DP  - 2011 Sep
TI  - Ninety-six novel HLA class I and II alleles identified in volunteers for the 
      National Marrow Donor Program Registry in 2009.
PG  - 195-202
LID - 10.1111/j.1399-0039.2011.01704.x [doi]
AB  - Ninety-six novel human leukocyte antigen (HLA) class I and class II alleles are 
      described from volunteers for the 'Be The Match Registry(R)': 15 HLA-A alleles, 11 
      HLA-C alleles, 36 HLA-B alleles and 34 HLA-DRB1 alleles. Sixty-eight ( approximately 71%) of 
      the 96 novel alleles are single nucleotide substitution variants when compared 
      with their most homologous allele. Twenty-three of these single nucleotide 
      variants are silent substitutions and one creates a non-expressed allele (B(*) 
      27:59N). The remaining novel alleles differ from their most similar allele by two 
      to five nucleotide substitutions. One of the novel HLA-A alleles (A(*) 11:52Q) is 
      of questionable expression because of a deletion of codon 11. Three of the novel 
      alleles encode amino acid changes at codons 63 (HLA-C), 88 (HLA-B) and 79 
      (HLA-DRB1) which have not previously been reported to be polymorphic in these 
      loci. Some of the new alleles encode novel codons and unique amino acid changes 
      at polymorphic positions in the HLA-A (codons 115, 149 and 168), HLA-C (codon 
      90), HLA-B (codons 23, 44, 70, 120 and 153) and HLA-DRB1 (codon 88) loci.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Lazaro, A M
AU  - Lazaro AM
AD  - Department of Pediatrics and C.W. Bill Young Marrow Donor Research and 
      Recruitment Program, Georgetown University Medical Center, Washington, DC, USA.
FAU - Xiao, Y
AU  - Xiao Y
FAU - Henry, J
AU  - Henry J
FAU - Ng, J
AU  - Ng J
FAU - Hurley, C K
AU  - Hurley CK
FAU - Posch, P E
AU  - Posch PE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110516
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Bone Marrow
MH  - Genotype
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-C Antigens/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Registries
MH  - Tissue Donors
MH  - Volunteers
EDAT- 2011/05/17 06:00
MHDA- 2012/01/31 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2012/01/31 06:00 [medline]
AID - 10.1111/j.1399-0039.2011.01704.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2011 Sep;78(3):195-202. doi: 10.1111/j.1399-0039.2011.01704.x. 
      Epub 2011 May 16.