PMID- 21569380
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20211020
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 11
DP  - 2011 May 12
TI  - Identification of peripheral inflammatory markers between normal control and 
      Alzheimer's disease.
PG  - 51
LID - 10.1186/1471-2377-11-51 [doi]
AB  - BACKGROUND: Multiple pathogenic factors may contribute to the pathophysiology of 
      Alzheimer's disease (AD). Peripheral blood markers have been used to assess 
      biochemical changes associated with AD and mild cognitive impairment (MCI) and 
      involved in their pathophysiology. METHODS: Plasma samples and clinical data were 
      obtained from participants in the Ansan Geriatric Study (AGE study). Plasma 
      concentrations of four candidate biomarkers were measured in the normal control 
      (NC), MCI, and AD group: interleukin-8 (IL-8), IL-10, monocyte chemoattractant 
      protein-1 (MCP-1), and tumor necrosis factor-alpha (TNF-alpha).Body mass index (BMI), 
      MMSE (Mini Mental State Examination), CDR(Clinical Dementia Rating) score and 
      homocystein level were recorded with social and demographic information. RESULTS: 
      Total of 59 subjects were randomly selected for this analysis [NC (n = 21), MCI(n 
      = 20) and AD(n = 18)]. In demographic data, educational year was correlated with 
      the diagnosis states (p < 0.0001). No significant differences in cardiovascular 
      disease, BMI and use of NSAIDs were found in MCI or AD group compared with NC 
      group, respectively. The involvement of inflammatory illness or conditions in 
      subjects, WBC count, fibrinogen and homocystein of the three groups, but no 
      significant differences were found in each groups. The plasma IL-8 level was 
      lower in MCI and AD patients compared with the normal control group 
      (respectively, p < 0.0001). The MCI and AD patients had similar MCP-1, IL-10, and 
      TNF-alpha level. CONCLUSIONS: Our study suggests the existence of an independent and 
      negative relationship between plasma IL-8 levels and functional status in MCI and 
      AD patients.
FAU - Kim, Sam-Moon
AU  - Kim SM
AD  - Center for Biomedical Science, Division of Brain Diseases, National Institute of 
      Health in Korea (KNIH), Osong Health Technology Administration Complex 643 
      Yeonje-ri, Gangoe-myeon, Chungcheongbuk-do, 363-951, Republic of Korea.
FAU - Song, Juhee
AU  - Song J
FAU - Kim, Seungwoo
AU  - Kim S
FAU - Han, Changsu
AU  - Han C
FAU - Park, Moon Ho
AU  - Park MH
FAU - Koh, Youngho
AU  - Koh Y
FAU - Jo, Sangmee Ahn
AU  - Jo SA
FAU - Kim, Young-Youl
AU  - Kim YY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110512
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 1.14.99.1 (PTGS2 protein, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/blood/*complications
MH  - Analysis of Variance
MH  - Biomarkers/blood
MH  - Cognition Disorders/blood/complications
MH  - Cyclooxygenase 2/*blood
MH  - Cytokines/*blood
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - *Inflammation/blood/diagnosis/etiology
MH  - Male
MH  - Psychiatric Status Rating Scales
MH  - Random Allocation
MH  - Retrospective Studies
PMC - PMC3120663
EDAT- 2011/05/17 06:00
MHDA- 2011/09/14 06:00
PMCR- 2011/05/12
CRDT- 2011/05/17 06:00
PHST- 2011/01/10 00:00 [received]
PHST- 2011/05/12 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
PHST- 2011/05/12 00:00 [pmc-release]
AID - 1471-2377-11-51 [pii]
AID - 10.1186/1471-2377-11-51 [doi]
PST - epublish
SO  - BMC Neurol. 2011 May 12;11:51. doi: 10.1186/1471-2377-11-51.