PMID- 21569485
OWN - NLM
STAT- MEDLINE
DCOM- 20110915
LR  - 20221207
IS  - 1471-2369 (Electronic)
IS  - 1471-2369 (Linking)
VI  - 12
DP  - 2011 May 13
TI  - The association of HLA-DQB1, -DQA1 and -DPB1 alleles with anti- glomerular 
      basement membrane (GBM) disease in Chinese patients.
PG  - 21
LID - 10.1186/1471-2369-12-21 [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA) alleles are associated with many 
      autoimmune diseases, including anti-glomerular basement membrane (GBM) disease. 
      In our previous study, it was demonstrated that HLA-DRB1*1501 was strongly 
      associated with anti-GBM disease in Chinese. However, the association of anti-GBM 
      disease and other HLA class II genes, including HLA-DQB1, -DQA1,-DPB1 alleles, 
      has rarely been investigated in Asian, especially Chinese patients. The present 
      study further analyzed the association between anti-GBM disease and HLA-DQB1, 
      -DQA1, and -DPB1 genes. Apart from this, we tried to locate the potential risk 
      amino acid residues of anti-GBM disease. METHODS: This study included 44 Chinese 
      patients with anti-GBM disease and 200 healthy controls. The clinical and 
      pathological data of the patients were collected and analyzed. Typing of 
      HLA-DQB1, -DQA1 and -DPB1 alleles were performed by bi-directional sequencing of 
      exon 2 using the SeCoreTM Sequencing Kits. RESULTS: Compared with normal 
      controls, the prevalence of HLA-DPB1*0401 was significantly lower in patients 
      with anti-GBM disease (3/88 vs. 74/400, p = 4.4 x 10-4, pc=0.039). Comparing with 
      normal controls, the combination of presence of DRB1*1501 and absence of 
      DPB1*0401 was significantly prominent among anti-GBM patients (p=2.0 x 10-12, 
      pc=1.7 x 10-10). CONCLUSIONS: HLA-DPB1*0401 might be a protective allele to 
      anti-GBM disease in Chinese patients. The combined presence of DRB1*1501 and 
      absence of DPB1*0401 might have an even higher risk to anti-GBM disease than 
      HLA-DRB1*1501 alone.
CI  - (c) 2011 Luo et al; licensee BioMed Central Ltd.
FAU - Luo, Huan
AU  - Luo H
AD  - Renal Division, Department of Medicine, Peking University First Hospital, 
      Institute of Nephrology, Peking University, Beijing 100034, China.
FAU - Chen, Min
AU  - Chen M
FAU - Cui, Zhao
AU  - Cui Z
FAU - Yang, Rui
AU  - Yang R
FAU - Xu, Peng-Cheng
AU  - Xu PC
FAU - Zhou, Xu-Jie
AU  - Zhou XJ
FAU - Zhao, Ming-Hui
AU  - Zhao MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110513
PL  - England
TA  - BMC Nephrol
JT  - BMC nephrology
JID - 100967793
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DPB1*04:01 antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*15:01 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Alleles
MH  - Anti-Glomerular Basement Membrane Disease/ethnology/*genetics
MH  - Asian People/ethnology/*genetics
MH  - Case-Control Studies
MH  - China
MH  - Exons/genetics
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - HLA-DP Antigens/*genetics
MH  - HLA-DP beta-Chains
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Young Adult
PMC - PMC3107170
EDAT- 2011/05/17 06:00
MHDA- 2011/09/16 06:00
PMCR- 2011/05/13
CRDT- 2011/05/17 06:00
PHST- 2010/12/04 00:00 [received]
PHST- 2011/05/13 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/09/16 06:00 [medline]
PHST- 2011/05/13 00:00 [pmc-release]
AID - 1471-2369-12-21 [pii]
AID - 10.1186/1471-2369-12-21 [doi]
PST - epublish
SO  - BMC Nephrol. 2011 May 13;12:21. doi: 10.1186/1471-2369-12-21.