PMID- 21569798
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20240109
IS  - 1872-9096 (Electronic)
IS  - 0166-3542 (Linking)
VI  - 91
IP  - 2
DP  - 2011 Aug
TI  - Antiviral activity of type I and type III interferons against porcine 
      reproductive and respiratory syndrome virus (PRRSV).
PG  - 99-101
LID - 10.1016/j.antiviral.2011.04.017 [doi]
AB  - The newly identified type III interferons (IFNs), also known as IFN-lambda1/IL-29, 
      IFN-lambda2/IL-28A and IFN-lambda3/IL-28B, like type I IFNs, have antiviral activity 
      against a broad spectrum of viruses. We therefore examined whether type III IFNs, 
      as well as type I IFNs, has the ability to inhibit porcine reproductive and 
      respiratory syndrome virus (PRRSV) replication in MARC-145 cells. We found that 
      replication of PRRSV in MARC-145 cells was significantly reduced following 
      treatment with IFN-lambda1, IFN-lambda2 and IFN-lambda3, respectively, and such inhibition was 
      dose-dependent. However, type III IFNs (IFN-lambda1, IFN-lambda2 and IFN-lambda3) was less 
      effective than type I IFNs (IFN-alpha and IFN-beta) in antiviral activity against PRRSV. 
      Mixture of two types of IFNs could not improve the antiviral activity of each 
      type alone. In addition, all types of IFNs in our study were able to induce the 
      expression of ISG56, 2',5'-OAS and MxA in MARC-145 cells. These data demonstrate 
      that type III IFNs had antiviral activity against PRRSV and may serve as useful 
      antiviral agents against infectious swine diseases.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Luo, Rui
AU  - Luo R
AD  - Division of Animal Infectious Diseases, State Key Laboratory of Agricultural 
      Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, 
      Wuhan 430070, China.
FAU - Fang, Liurong
AU  - Fang L
FAU - Jin, Hui
AU  - Jin H
FAU - Jiang, Yunbo
AU  - Jiang Y
FAU - Wang, Dang
AU  - Wang D
FAU - Chen, Huanchun
AU  - Chen H
FAU - Xiao, Shaobo
AU  - Xiao S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110504
PL  - Netherlands
TA  - Antiviral Res
JT  - Antiviral research
JID - 8109699
RN  - 0 (Antiviral Agents)
RN  - 0 (interferon-lambda, human)
RN  - 0 (Interferon Type I)
RN  - 0 (Interleukins)
RN  - 0 (Recombinant Proteins)
RN  - 9008-11-1 (Interferons)
RN  - EC 2.7.7.84 (2',5'-Oligoadenylate Synthetase)
SB  - IM
MH  - 2',5'-Oligoadenylate Synthetase/metabolism
MH  - Animals
MH  - Antiviral Agents/pharmacology
MH  - Cell Line
MH  - Chlorocebus aethiops
MH  - Interferon Type I/*pharmacology
MH  - Interferons
MH  - Interleukins/*pharmacology
MH  - Microbial Sensitivity Tests
MH  - Porcine respiratory and reproductive syndrome virus/*drug 
      effects/immunology/physiology
MH  - Recombinant Proteins/pharmacology
MH  - Viral Plaque Assay
MH  - Virus Replication
EDAT- 2011/05/17 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/05/17 06:00
PHST- 2010/11/17 00:00 [received]
PHST- 2011/04/22 00:00 [revised]
PHST- 2011/04/27 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - S0166-3542(11)00296-8 [pii]
AID - 10.1016/j.antiviral.2011.04.017 [doi]
PST - ppublish
SO  - Antiviral Res. 2011 Aug;91(2):99-101. doi: 10.1016/j.antiviral.2011.04.017. Epub 
      2011 May 4.