PMID- 21570223
OWN - NLM
STAT- MEDLINE
DCOM- 20120615
LR  - 20120213
IS  - 1879-1476 (Electronic)
IS  - 0385-8146 (Linking)
VI  - 39
IP  - 2
DP  - 2012 Apr
TI  - Reduced E-cadherin expression is associated with lymph node metastases in 
      laryngeal squamous cell carcinoma.
PG  - 186-92
LID - 10.1016/j.anl.2011.04.003 [doi]
AB  - OBJECTIVE: To investigate the expression of E-cadherin and its relationship with 
      clinicopathological parameters in laryngeal squamous cell carcinoma (LSCC). 
      METHODS: Sixty-four patients who had previously undergone complete resection of 
      tumor for LSCC were studied retrospectively. The level of E-cadherin expression 
      in tumor tissues and paired nontumor tissues were determined by 
      immunohistochemistry. RESULTS: The expression of E-cadherin in tumor tissues was 
      significantly lower than nontumor tissues (P<0.001). Reduced E-cadherin 
      expression was significantly correlated with lymph node metastases (P<0.001). 
      Kaplan-Meier survival estimates showed a significant correlation between 
      E-cadherin expression and patient survival rate (log-rank P<0.05). Multivariate 
      Cox proportional hazards model analysis confirmed that lymph node metastases 
      (P=0.001) and tumor stage (P=0.013) were statistically significant, independent 
      predictor of prognosis. CONCLUSION: Expression of E-cadherin is an independent 
      predictor of lymph node metastases in LSCC. However, it does not appear to be a 
      better prognostic predictor than other established markers in LSCC.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Li, Jing-jia
AU  - Li JJ
AD  - Department of Otolaryngology-Head and Neck Surgery, the Third Affiliated Hospital 
      of Sun Yat-Sen University, Guangzhou, Guangdong, PR China.
FAU - Zhang, Ge-hua
AU  - Zhang GH
FAU - Yang, Xin-ming
AU  - Yang XM
FAU - Li, Shi-sheng
AU  - Li SS
FAU - Liu, Xian
AU  - Liu X
FAU - Yang, Qin-tai
AU  - Yang QT
FAU - Li, Yuan
AU  - Li Y
FAU - Ye, Jin
AU  - Ye J
LA  - eng
PT  - Journal Article
DEP - 20110513
PL  - Netherlands
TA  - Auris Nasus Larynx
JT  - Auris, nasus, larynx
JID - 7708170
RN  - 0 (Cadherins)
SB  - IM
MH  - Aged
MH  - Cadherins/*analysis
MH  - Carcinoma, Squamous Cell/*pathology/surgery
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Laryngeal Neoplasms/*pathology/surgery
MH  - Laryngectomy
MH  - Larynx/pathology
MH  - Lymph Nodes/pathology
MH  - Lymphatic Metastasis/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neck Dissection
MH  - Neoplasm Staging
MH  - Reference Values
MH  - Retrospective Studies
EDAT- 2011/05/17 06:00
MHDA- 2012/06/16 06:00
CRDT- 2011/05/17 06:00
PHST- 2010/12/27 00:00 [received]
PHST- 2011/04/07 00:00 [revised]
PHST- 2011/04/13 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2012/06/16 06:00 [medline]
AID - S0385-8146(11)00131-3 [pii]
AID - 10.1016/j.anl.2011.04.003 [doi]
PST - ppublish
SO  - Auris Nasus Larynx. 2012 Apr;39(2):186-92. doi: 10.1016/j.anl.2011.04.003. Epub 
      2011 May 13.