PMID- 21570441
OWN - NLM
STAT- MEDLINE
DCOM- 20110926
LR  - 20240109
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 49
IP  - 8
DP  - 2011 Aug
TI  - Anti-inflammatory effects of fucoidan through inhibition of NF-kappaB, MAPK and Akt 
      activation in lipopolysaccharide-induced BV2 microglia cells.
PG  - 1745-52
LID - 10.1016/j.fct.2011.04.020 [doi]
AB  - Fucoidan, a sulfated polysaccharide extracted from brown seaweed, displays a wide 
      variety of internal biological activities; however, the cellular and molecular 
      mechanisms underlying fucoidan's anti-inflammatory activity remain poorly 
      understood. In this study, we investigated the inhibitory effects of fucoidan on 
      production of lipopolysaccharide (LPS)-induced pro-inflammatory mediators in BV2 
      microglia. Our data indicated that fucoidan treatment significantly inhibited 
      excessive production of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) in 
      LPS-stimulated BV2 microglia. It also attenuated expression of inducible nitric 
      oxide synthase (iNOS), cyclooxygenase (COX)-2, monocyte chemoattractant protein-1 
      (MCP-1), and pro-inflammatory cytokines, including interleukin-1beta (IL-1beta) and 
      tumor necrosis factor (TNF)-alpha. Moreover, fucoidan exhibited anti-inflammatory 
      properties by suppression of nuclear factor-kappa B (NF-kappaB) activation and 
      down-regulation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal 
      kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and AKT pathways. 
      These finding suggest that fucoidan may offer substantial therapeutic potential 
      for treatment of neurodegenerative diseases that are accompanied by microglial 
      activation.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Park, Hye Young
AU  - Park HY
AD  - Department of Pharmacy, Pusan National University, Busan 609-735, Republic of 
      Korea.
FAU - Han, Min Ho
AU  - Han MH
FAU - Park, Cheol
AU  - Park C
FAU - Jin, Cheng-Yun
AU  - Jin CY
FAU - Kim, Gi-Young
AU  - Kim GY
FAU - Choi, Il-Whan
AU  - Choi IW
FAU - Kim, Nam Deuk
AU  - Kim ND
FAU - Nam, Taek-Jeong
AU  - Nam TJ
FAU - Kwon, Taeg Kyu
AU  - Kwon TK
FAU - Choi, Yung Hyun
AU  - Choi YH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110504
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NF-kappa B)
RN  - 0 (Plant Extracts)
RN  - 0 (Polysaccharides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 9072-19-9 (fucoidan)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Cells, Cultured
MH  - Chemokine CCL2/genetics/metabolism
MH  - Cyclooxygenase 2/genetics/metabolism
MH  - Dinoprostone/antagonists & inhibitors/metabolism
MH  - Down-Regulation
MH  - Fucus/chemistry
MH  - Interleukin-1beta/genetics/metabolism
MH  - JNK Mitogen-Activated Protein Kinases/genetics/metabolism
MH  - Lipopolysaccharides/adverse effects
MH  - Mice
MH  - Microglia/cytology/*drug effects/metabolism
MH  - Mitogen-Activated Protein Kinases/*antagonists & inhibitors/genetics/metabolism
MH  - NF-kappa B/*antagonists & inhibitors/genetics/metabolism
MH  - Nitric Oxide/antagonists & inhibitors/metabolism
MH  - Nitric Oxide Synthase Type II/genetics/metabolism
MH  - Plant Extracts/pharmacology
MH  - Polysaccharides/*pharmacology
MH  - Proto-Oncogene Proteins c-akt/*antagonists & inhibitors/genetics/metabolism
MH  - Rabbits
MH  - Tumor Necrosis Factor-alpha/genetics/metabolism
MH  - p38 Mitogen-Activated Protein Kinases/genetics/metabolism
EDAT- 2011/05/17 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/05/17 06:00
PHST- 2010/11/15 00:00 [received]
PHST- 2011/03/26 00:00 [revised]
PHST- 2011/04/19 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S0278-6915(11)00168-2 [pii]
AID - 10.1016/j.fct.2011.04.020 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2011 Aug;49(8):1745-52. doi: 10.1016/j.fct.2011.04.020. Epub 
      2011 May 4.