PMID- 21570564
OWN - NLM
STAT- MEDLINE
DCOM- 20110912
LR  - 20171116
IS  - 0151-9638 (Print)
IS  - 0151-9638 (Linking)
VI  - 138
IP  - 5
DP  - 2011 May
TI  - [Primitive cutaneous Ewing's sarcoma: a diagnostic and therapeutic dilemma].
PG  - 395-8
LID - 10.1016/j.annder.2010.11.010 [doi]
AB  - BACKGROUND: Ewing's sarcoma (or peripheral neuroectodermal tumour) is generally 
      found in bone tissue, and a primary dermal site is extremely rare. We report a 
      case of primary cutaneous Ewing's sarcoma in a 21-year-old woman. PATIENTS AND 
      METHODS: A 21-year-old woman presented with a scapular lesion that had been 
      slowly developing for one year. The 1-cm lesion was removed and histological 
      examination showed proliferation of small round cells in the dermis. 
      Immunostaining revealed cytoplasmic membrane expression of CD99 and a negative 
      immunoprofile for other small round-cell tumors. Ewing's sarcoma fusion gene 
      transcripts were detected using fluorescence in situ hybridization (FISH). A 
      staging examination revealed no other abnormalities. It was decided to treat the 
      lesion as for osseous Ewing's sarcoma with wide resection followed by systemic 
      adjuvant chemotherapy. DISCUSSION: Cutaneous Ewing's sarcoma raises concerns 
      about diagnosis and treatment. Owing to the non-specificity of its clinical 
      presentation, histology and immunoprofile, diagnosis of superficial Ewing's 
      sarcoma is difficult and numerous differential diagnoses must be considered. When 
      dealing with a surface tumour, the diagnosis of cutaneous Ewing's sarcoma must be 
      considered. CD99 immunostaining and molecular testing for evidence of EWSR1 
      rearrangement are useful investigations to confirm the diagnosis. Furthermore, 
      modalities of treatment must be carefully discussed. Cutaneous Ewing's sarcoma is 
      currently treated in the same way as osseous Ewing's sarcoma (wide surgical 
      excision, adjuvant radiotherapy when surgical margins are unsatisfactory, 
      systemic adjuvant chemotherapy, and, in some cases, bone marrow transplant). 
      However, some studies show a more favourable prognosis for cutaneous Ewing's 
      sarcoma than for osseous Ewing's sarcoma. We may thus ask whether such aggressive 
      multimodal treatment is needed.
CI  - Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
FAU - Delaplace, M
AU  - Delaplace M
AD  - Service de dermatologie, hopital Trousseau, CHU de Tours, Tours, France.
FAU - Melard, P
AU  - Melard P
FAU - Perrinaud, A
AU  - Perrinaud A
FAU - Gore, C
AU  - Gore C
FAU - Vergier, B
AU  - Vergier B
FAU - Machet, L
AU  - Machet L
LA  - fre
PT  - Case Reports
PT  - Journal Article
TT  - Sarcome d'Ewing cutane primitif : difficultes diagnostiques et therapeutiques.
DEP - 20101224
PL  - France
TA  - Ann Dermatol Venereol
JT  - Annales de dermatologie et de venereologie
JID - 7702013
RN  - 0 (12E7 Antigen)
RN  - 0 (Antigens, CD)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CD99 protein, human)
RN  - 0 (Calmodulin-Binding Proteins)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (EWSR1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA-Binding Protein EWS)
RN  - 0 (RNA-Binding Proteins)
RN  - 1CC1JFE158 (Dactinomycin)
RN  - 5J49Q6B70F (Vincristine)
RN  - 6PLQ3CP4P3 (Etoposide)
RN  - 80168379AG (Doxorubicin)
RN  - UM20QQM95Y (Ifosfamide)
SB  - IM
MH  - 12E7 Antigen
MH  - Antigens, CD/analysis
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Biomarkers, Tumor/analysis
MH  - Calmodulin-Binding Proteins/genetics
MH  - Cell Adhesion Molecules/analysis
MH  - *Chemotherapy, Adjuvant
MH  - Combined Modality Therapy
MH  - Dactinomycin/administration & dosage
MH  - Disease Management
MH  - Doxorubicin/administration & dosage
MH  - Etoposide/administration & dosage
MH  - Female
MH  - Humans
MH  - Ifosfamide/administration & dosage
MH  - In Situ Hybridization, Fluorescence
MH  - Neoplasm Proteins/analysis
MH  - RNA-Binding Protein EWS
MH  - RNA-Binding Proteins/genetics
MH  - Reoperation
MH  - Sarcoma, Ewing/chemistry/*diagnosis/drug therapy/genetics/pathology/surgery
MH  - Shoulder
MH  - Skin Neoplasms/chemistry/*diagnosis/drug therapy/genetics/pathology/surgery
MH  - Vincristine/administration & dosage
MH  - Young Adult
EDAT- 2011/05/17 06:00
MHDA- 2011/09/13 06:00
CRDT- 2011/05/17 06:00
PHST- 2010/07/08 00:00 [received]
PHST- 2010/09/26 00:00 [revised]
PHST- 2010/11/17 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/09/13 06:00 [medline]
AID - S0151-9638(10)00559-4 [pii]
AID - 10.1016/j.annder.2010.11.010 [doi]
PST - ppublish
SO  - Ann Dermatol Venereol. 2011 May;138(5):395-8. doi: 10.1016/j.annder.2010.11.010. 
      Epub 2010 Dec 24.