PMID- 21570993
OWN - NLM
STAT- MEDLINE
DCOM- 20111103
LR  - 20171116
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 104
IP  - 3
DP  - 2011 Sep 1
TI  - Prenatal LPS exposure reduces olfactory perception in neonatal and adult rats.
PG  - 417-22
LID - 10.1016/j.physbeh.2011.04.049 [doi]
AB  - Prenatal lipopolysaccharide (LPS) exposure causes reproductive, behavioral and 
      neurochemical defects in both dams and pups. The present study evaluated male 
      rats prenatally treated with LPS for behavioral and neurological effects related 
      to the olfactory system, which is the main sensorial path in rodents. Pregnant 
      Wistar rats received 100 mug/kg of LPS intraperitoneally (i.p.) on gestational day 
      (GD) 9.5, and maternal behavior was evaluated. Pups were evaluated for (1) 
      maternal odor preference, (2) aversion to cat odor, (3) monoamine levels and 
      turnover in the olfactory bulb (OB) and (4) protein expression (via 
      immunoblotting) within the OB dopaminergic system and glial cells. Results showed 
      that prenatal LPS exposure impaired maternal preference and cat odor aversion and 
      decreased dopamine (DA) levels in the OB. This dopaminergic impairment may have 
      been due to defects in another brain area given that protein expression of the 
      first enzyme in the DA biosynthetic pathway was unchanged in the OB. Moreover, 
      there was no change in the protein expression of the DA receptors. The fact that 
      the number of astrocytes and microglia was not increased suggests that prenatal 
      LPS did not induce neuroinflammation in the OB. Furthermore, given that maternal 
      care was not impaired, abnormalities in the offspring were not the result of 
      reduced maternal care.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Kirsten, Thiago Berti
AU  - Kirsten TB
AD  - Department of Pathology, School of Veterinary Medicine, University of Sao Paulo, 
      Av. Prof. Dr. Orlando Marques de Paiva, 87, 05508-270, Sao Paulo, SP, Brazil. 
      thik@hotmail.com
FAU - Chaves, Gabriela Pena
AU  - Chaves GP
FAU - Taricano, Marina
AU  - Taricano M
FAU - Martins, Daniel Oliveira
AU  - Martins DO
FAU - Florio, Jorge Camilo
AU  - Florio JC
FAU - Britto, Luiz Roberto Giorgetti de
AU  - Britto LR
FAU - Torrao, Andrea da Silva
AU  - Torrao AS
FAU - Palermo-Neto, Joao
AU  - Palermo-Neto J
FAU - Bernardi, Maria Martha
AU  - Bernardi MM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110503
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Biogenic Monoamines)
RN  - 0 (CD11b Antigen)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Receptors, Dopamine)
SB  - IM
MH  - Age Factors
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Biogenic Monoamines/metabolism
MH  - CD11b Antigen/metabolism
MH  - Female
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Lipopolysaccharides/*toxicity
MH  - Male
MH  - Maternal Behavior/drug effects
MH  - Odorants
MH  - Olfactory Bulb/metabolism
MH  - Olfactory Perception/*drug effects
MH  - Perceptual Disorders/*etiology/pathology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced/*physiopathology
MH  - Rats
MH  - Receptors, Dopamine/metabolism
EDAT- 2011/05/17 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/01/11 00:00 [received]
PHST- 2011/04/04 00:00 [revised]
PHST- 2011/04/25 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - S0031-9384(11)00208-3 [pii]
AID - 10.1016/j.physbeh.2011.04.049 [doi]
PST - ppublish
SO  - Physiol Behav. 2011 Sep 1;104(3):417-22. doi: 10.1016/j.physbeh.2011.04.049. Epub 
      2011 May 3.