PMID- 21571262
OWN - NLM
STAT- MEDLINE
DCOM- 20110826
LR  - 20220311
IS  - 1090-2163 (Electronic)
IS  - 0008-8749 (Linking)
VI  - 269
IP  - 2
DP  - 2011
TI  - Effect of age on surface molecules and cytokine expression in human dendritic 
      cells.
PG  - 82-9
LID - 10.1016/j.cellimm.2011.04.010 [doi]
AB  - Dendritic cells (DCs) are central in regulating both innate and acquired 
      immunity, but their possible age-related functional modifications are still 
      unclear. Here we have analyzed the effect of age on LPS-treated monocyte-derived 
      DCs (MDDCs). A negative correlation between age and cell expression of ICAM-1, 
      CD25 and IL-10 was observed in a group of healthy donors. This has been confirmed 
      by a significantly reduced expression of the same molecules in cells of 
      subgrouped elderly versus younger individuals. On the contrary, a positive 
      correlation between age and cell expression of IL-6 and IL-18 has been reported 
      in all the subjects and further supported by a significant increase of the two 
      pro-inflammatory cytokines in cells of elderly versus young subjects. Our data 
      indicate that aging can impair the expression of ICAM-1 and CD25 and skew the 
      production of cytokines, including IL-18, which concur to make a pro-inflammatory 
      milieu. Altogether, the present results point to additional molecules whose role 
      might be relevant in immunosenescence of human DCs, confirming that these cells 
      undergo functional changes during aging.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Ciaramella, Antonio
AU  - Ciaramella A
AD  - Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, 
      Via Ardeatina 306, 00179 Rome, Italy. a.ciaramella@hsantalucia.it
FAU - Spalletta, Gianfranco
AU  - Spalletta G
FAU - Bizzoni, Federica
AU  - Bizzoni F
FAU - Salani, Francesca
AU  - Salani F
FAU - Caltagirone, Carlo
AU  - Caltagirone C
FAU - Bossu, Paola
AU  - Bossu P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110427
PL  - Netherlands
TA  - Cell Immunol
JT  - Cellular immunology
JID - 1246405
RN  - 0 (Antigens, CD)
RN  - 0 (Cytokines)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (IL10 protein, human)
RN  - 0 (IL2RA protein, human)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-2 Receptor alpha Subunit)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Membrane Proteins)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*immunology/*metabolism
MH  - Antigens, CD/metabolism
MH  - Cell Differentiation/drug effects/immunology
MH  - Cytokines/immunology/*metabolism
MH  - Dendritic Cells/cytology/immunology/*metabolism
MH  - Female
MH  - HLA-DR Antigens/metabolism
MH  - Histocompatibility Antigens Class I/metabolism
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/metabolism
MH  - Interleukin-10/metabolism
MH  - Interleukin-18/metabolism
MH  - Interleukin-2 Receptor alpha Subunit/metabolism
MH  - Interleukin-6/metabolism
MH  - Lipopolysaccharides/pharmacology
MH  - Male
MH  - Membrane Proteins/*metabolism
MH  - Middle Aged
MH  - Monocytes/cytology/drug effects
MH  - Young Adult
EDAT- 2011/05/17 06:00
MHDA- 2011/08/30 06:00
CRDT- 2011/05/17 06:00
PHST- 2010/10/29 00:00 [received]
PHST- 2011/04/08 00:00 [revised]
PHST- 2011/04/20 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - S0008-8749(11)00098-0 [pii]
AID - 10.1016/j.cellimm.2011.04.010 [doi]
PST - ppublish
SO  - Cell Immunol. 2011;269(2):82-9. doi: 10.1016/j.cellimm.2011.04.010. Epub 2011 Apr 
      27.