PMID- 21572006
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20211020
IS  - 1522-1539 (Electronic)
IS  - 0363-6135 (Print)
IS  - 0363-6135 (Linking)
VI  - 301
IP  - 2
DP  - 2011 Aug
TI  - Postmaximal contraction blood volume responses are blunted in obese and type 2 
      diabetic subjects in a muscle-specific manner.
PG  - H418-27
LID - 10.1152/ajpheart.00060.2011 [doi]
AB  - The purpose of this study was to determine whether there are differences in 
      postisometric contraction blood volume and oxygenation responses among groups of 
      type 2 diabetes mellitus (T2DM), obese, and lean individuals detectable using 
      MRI. Eight T2DM patients were individually matched by age, sex, and race to 
      non-T2DM individuals with similar body mass index (obese) and lean subjects. 
      Functional MRI was performed using a dual-gradient-recalled echo, echo-planar 
      imaging sequence with a repetition time of 1 s and at two echo times (TE = 6 and 
      46 ms). Data were acquired before, during, and after 10-s isometric dorsiflexion 
      contractions performed at 50 and 100% of maximal voluntary contraction (MVC) 
      force. MRI signal intensity (SI) changes from the tibialis anterior and extensor 
      digitorum longus muscles were plotted as functions of time for each TE. From each 
      time course, the difference between the minimum and the maximum postcontraction 
      SI (DeltaSI) were determined for TE = 6 ms (DeltaSI(6)) and TE = 46 ms (DeltaSI(46)), 
      reflecting variations in blood volume and oxyhemoglobin saturation, respectively. 
      Following 50% MVC contractions, the mean postcontraction DeltaSI(6) values were 
      similar in the three groups. Following MVC only, and in the EDL muscle only, T2DM 
      and obese participants had  approximately 56% lower DeltaSI(6) than the lean individuals. Also 
      following MVC only, the DeltaSI(46) response in the EDL was lower in T2DM subjects 
      than in lean individuals. These data suggest that skeletal muscle small vessel 
      impairment occurs in T2DM and body mass index-matched subjects, in 
      muscle-specific and contraction intensity-dependent manners.
FAU - Sanchez, Otto A
AU  - Sanchez OA
AD  - Institute of Imaging Science, Department of Medicine, Vanderbilt University, 
      Nashville, Tennessee, USA.
FAU - Copenhaver, Elizabeth A
AU  - Copenhaver EA
FAU - Chance, Marti A
AU  - Chance MA
FAU - Fowler, Michael J
AU  - Fowler MJ
FAU - Towse, Theodore F
AU  - Towse TF
FAU - Kent-Braun, Jane A
AU  - Kent-Braun JA
FAU - Damon, Bruce M
AU  - Damon BM
LA  - eng
GR  - R21 DK076880/DK/NIDDK NIH HHS/United States
GR  - T32 EB001628/EB/NIBIB NIH HHS/United States
GR  - UL1 RR024975/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110513
PL  - United States
TA  - Am J Physiol Heart Circ Physiol
JT  - American journal of physiology. Heart and circulatory physiology
JID - 100901228
RN  - 0 (Oxyhemoglobins)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - *Blood Volume
MH  - Diabetes Mellitus, Type 2/blood/*physiopathology
MH  - Female
MH  - Humans
MH  - *Isometric Contraction
MH  - Linear Models
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Microcirculation
MH  - Middle Aged
MH  - Muscle, Skeletal/*blood supply/metabolism/physiopathology
MH  - Obesity/blood/*physiopathology
MH  - Oxygen/blood
MH  - Oxygen Consumption
MH  - Oxyhemoglobins/metabolism
MH  - Regional Blood Flow
MH  - Time Factors
PMC - PMC3154659
EDAT- 2011/05/17 06:00
MHDA- 2011/10/01 06:00
PMCR- 2012/08/01
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
PHST- 2012/08/01 00:00 [pmc-release]
AID - ajpheart.00060.2011 [pii]
AID - H-00060-2011 [pii]
AID - 10.1152/ajpheart.00060.2011 [doi]
PST - ppublish
SO  - Am J Physiol Heart Circ Physiol. 2011 Aug;301(2):H418-27. doi: 
      10.1152/ajpheart.00060.2011. Epub 2011 May 13.