PMID- 21572733
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220408
IS  - 0975-1599 (Electronic)
IS  - 0974-9233 (Print)
IS  - 0974-9233 (Linking)
VI  - 18
IP  - 1
DP  - 2011 Jan
TI  - Change in quality of life after medical and surgical treatment of graves' 
      ophthalmopathy.
PG  - 42-7
LID - 10.4103/0974-9233.75884 [doi]
AB  - PURPOSE: To assess the changes in quality of life (QOL) of patients after 
      treatment of their Graves' ophthalmopathy (GO). MATERIALS AND METHODS: In this 
      prospective, cross-sectional study, the GO-QOL questionnaire was completed by 67 
      subjects before and at least 6 months after steroid treatment (61 subjects, group 
      1) or optic neuropathy orbital decompression (6 subjects, group 2). Visual, 
      psychosocial, education and counseling scores (higher score = better health), GO 
      severity and clinical activity scores and minimal clinically important difference 
      (MCID) were recorded and analyzed for correlation and statistical significance. A 
      P-value <0.05 was considered statistically significant. RESULTS: The mean age of 
      patient enrolled in the study was 38.3 years, with 43 females (64.2%). The mean 
      duration of thyroid dysfunction and GO were 40.1 and 26.5 months, respectively. 
      Two treatment groups were similar for all the variables (0.06 < P < 0.9), except 
      for higher mean age in the orbital decompression group (45.2 versus 37.7 years) 
      (P = 0.03). Mean severity, activity, visual function and psychosocial function 
      scores significantly improved in group 1 (steroid group) (P < 0.05, all cases). A 
      significant improvement in clinical activity score and psychosocial scores 
      occurred in group 2 (decompression group) (P < 0.05). MCID was achieved in 
      two-thirds of the patients, with no significant difference between groups (P > 
      0.05). There was no significant effect of duration of thyroid disease and GO and 
      severity and activity of GO on QOL scores either before or after treatment (P > 
      0.05, all cases). CONCLUSION: Steroid treatment and orbital decompression 
      significantly improve the QOL in GO. Duration, severity and activity of GO did 
      not have a significant impact on the QOL.
FAU - Kashkouli, Mohsen Bahmani
AU  - Kashkouli MB
AD  - Department of Eye, Eye Research Center, Rassoul Akram Hospital, Iran University 
      of Medical Sciences, Tehran, Iran.
FAU - Heidari, Iraj
AU  - Heidari I
FAU - Pakdel, Farzad
AU  - Pakdel F
FAU - Jam, Sara
AU  - Jam S
FAU - Honarbakhsh, Yasamin
AU  - Honarbakhsh Y
FAU - Mirarmandehi, Bahareh
AU  - Mirarmandehi B
LA  - eng
PT  - Journal Article
PL  - India
TA  - Middle East Afr J Ophthalmol
JT  - Middle East African journal of ophthalmology
JID - 101521797
PMC - PMC3085151
OTO - NOTNLM
OT  - Eyelid Retraction
OT  - Graves' Ophthalmopathy
OT  - Proptosis
OT  - Quality of Life
COIS- Conflict of Interest: None declared
EDAT- 2011/05/17 06:00
MHDA- 2011/05/17 06:01
PMCR- 2011/01/01
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/05/17 06:01 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - MEAJO-18-42 [pii]
AID - 10.4103/0974-9233.75884 [doi]
PST - ppublish
SO  - Middle East Afr J Ophthalmol. 2011 Jan;18(1):42-7. doi: 10.4103/0974-9233.75884.