PMID- 21573444
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20190606
IS  - 1019-6439 (Print)
IS  - 1019-6439 (Linking)
VI  - 3
IP  - 5
DP  - 1993 Nov
TI  - Sequential and progressive cyclin expression in human osteosarcoma cells - 
      diagnostic and therapeutic implications.
PG  - 859-67
AB  - Cyclin proteins in association with cyclin-dependent protein kinase (Cdk) 
      subunits function to execute critical cell cycle transitions; dysregulation of 
      these enzymes may play a pivotal role in human tumorigenesis. In this study we 
      characterize the successive expression of cyclins D1, E, A, and B, as well as a 
      novel cyclin-like protein, in synchronized human MG-63 osteosarcoma cells. The 
      physiological activation, subunit configuration, and subcellular localization of 
      cyclin D1 during the G1 phase of the cell cycle is characterized in additional 
      detail. An essential role for cyclin D1 in osteosarcoma cell proliferation is 
      inferred by the efficacy of an antisense oligo-deoxynucleotide strategy directed 
      against this locus. In addition, we report on the amplification and comparative 
      over-expression of cyclin D1 in a Ewing's sarcoma cell line. These findings 
      support a sequential model of cyclin expression and suggest that examination of 
      the levels of specific cyclins may provide valuable diagnostic and/or prognostic 
      information in the evaluation of proliferative disorders.
FAU - Wu, L
AU  - Wu L
AD  - UNIV SO CALIF,CHILDRENS HOSP LOS ANGELES,SCH MED,DIV ORTHOPAED SURG,4650 SUNSET 
      BLVD,LOS ANGELES,CA 90027. UNIV SO CALIF,SCH PHARM,DEPT MOLEC PHARMACOL & 
      TOXICOL,LOS ANGELES,CA 90027.
FAU - Williams, R
AU  - Williams R
FAU - Carbonarohall, D
AU  - Carbonarohall D
FAU - Liu, L
AU  - Liu L
FAU - Tolo, V
AU  - Tolo V
FAU - Hall, F
AU  - Hall F
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Int J Oncol
JT  - International journal of oncology
JID - 9306042
EDAT- 1993/11/01 00:00
MHDA- 1993/11/01 00:01
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 1993/11/01 00:00 [pubmed]
PHST- 1993/11/01 00:01 [medline]
AID - 10.3892/ijo.3.5.859 [doi]
PST - ppublish
SO  - Int J Oncol. 1993 Nov;3(5):859-67. doi: 10.3892/ijo.3.5.859.