PMID- 21573529
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110516
IS  - 1019-6439 (Print)
IS  - 1019-6439 (Linking)
VI  - 2
IP  - 2
DP  - 1993 Feb
TI  - Amplification of protooncogenes in human ovarian carcinomas.
PG  - 155-60
AB  - Amplification of the proto-oncogenes c-myc, c-erbB2, c-K-ras2, c-H-ras1, c-erbA1, 
      c-int2 and c-fms was studied by Southern-blot analysis of DNA extracted from 27 
      primary ovarian carcinomas. In addition, karyotype analysis and interphase 
      cytogenetics using fluorescence in situ hybridization (FISH) were applied to 
      control the chromosomal variability of the tumors. By these additional analyses 
      the possibility of a false estimation of the grades of amplification should be 
      diminished. In nearly 50% of the studied tumors a low to moderate (2- to 10-fold) 
      amplification of one or more oncogenes was detected. The proto-oncogene amplified 
      most frequently was c-myc (11 tumors), followed by c-erbB2 and c-Kras2 (3 tumors 
      each), c-fms (2 tumors), and c-int2 (1 tumor). Neither an amplification of 
      c-erbA1 nor of c-H-ras1 could be detected in any of the tumors. Some of the 
      tumors showed a simultaneous amplification of two or three oncogenes. The pattern 
      of proto-oncogene amplification clearly differentiates the studied ovarian 
      cancers from breast tumors, but also differs from some previous results obtained 
      from ovarian carcinomas.
FAU - Liehr, T
AU  - Liehr T
AD  - UNIV ERLANGEN NURNBERG,INST HUMAN GENET,SCHWABACHANLAGE 10,W-8520 
      ERLANGEN,GERMANY. UNIV ERLANGEN NURNBERG,GYNECOL CLIN,W-8520 ERLANGEN,GERMANY.
FAU - Atanasov, N
AU  - Atanasov N
FAU - Tulusan, H
AU  - Tulusan H
FAU - Gebhart, E
AU  - Gebhart E
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Int J Oncol
JT  - International journal of oncology
JID - 9306042
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PST - ppublish
SO  - Int J Oncol. 1993 Feb;2(2):155-60.