PMID- 21574001
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20180126
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 48
IP  - 4
DP  - 2011 Dec
TI  - HBV and HCV infection in type 2 diabetes mellitus: a survey in three diabetes 
      units in different Italian areas.
PG  - 337-343
LID - 10.1007/s00592-011-0293-x [doi]
AB  - Viral infections and the metabolic syndrome may coexist in several individuals, 
      due to the large prevalence of obesity and type 2 diabetes mellitus (T2DM). 
      Antiviral therapy has changed the natural history of chronic viral hepatitis, but 
      viral infection may remain undiagnosed in the absence of systematic screening. We 
      determined the prevalence of HBV and/or HCV infection in an Italian cohort with 
      T2DM (859 consecutive patients, 413 females) in three Italian centers: Turin, 
      Bologna, and Naples. Screening for viral disease was coupled with the 
      determination of parameters of metabolic syndrome. Fourteen patients were 
      HBsAg-positive, 51 anti-HCV with a prevalence of genotype-1 infection in 58% of 
      cases. Thirty cases had newly diagnosed viral markers, only one-third had 
      already-diagnosed liver disease, 16 were being followed-up by a Liver Unit, and 9 
      cases had received antiviral treatment. Patients with viral markers had higher 
      liver enzyme levels in comparison with virus-negative patients (P < 0.0001), 
      whereas the prevalence of the metabolic syndrome was similar in the 2 groups. A 
      positive correlation between BMI and alanine aminostransferase levels was only 
      present in virus-negative cases, where the probability of enzyme levels above the 
      upper limit of normal increased by 5% for unit of increase in BMI (OR: 1.05; 95% 
      CI: 1.003-1.100, P = 0.037). In conclusion, the prevalence of HBV and HCV is 
      non-negligible in patients with T2DM, but these cases may long remain 
      undiagnosed. Elevated liver enzymes might be frequently disregarded in diabetes 
      Units and ascribed to metabolic syndrome, thus excluding T2DM patients from 
      specific disease-modifying antiviral treatment for hepatitis.
FAU - Soverini, Valentina
AU  - Soverini V
AD  - Unit of Metabolic Diseases and Clinical Dietetics, "Alma Mater Studiorum" 
      University of Bologna, Policlinico S. Orsola, Via Massarenti, 9, 40138, Bologna, 
      Italy.
FAU - Persico, Marcello
AU  - Persico M
AD  - Division of Internal Medicine and Hepatology, II degrees  University of Naples, Naples, 
      Italy.
FAU - Bugianesi, Elisabetta
AU  - Bugianesi E
AD  - Division of Gastroenterology and Hepatology, University of Turin, Turin, Italy.
FAU - Forlani, Gabriele
AU  - Forlani G
AD  - Unit of Metabolic Diseases and Clinical Dietetics, "Alma Mater Studiorum" 
      University of Bologna, Policlinico S. Orsola, Via Massarenti, 9, 40138, Bologna, 
      Italy.
FAU - Salamone, Federico
AU  - Salamone F
AD  - Division of Gastroenterology and Hepatology, University of Turin, Turin, Italy.
FAU - Masarone, Mario
AU  - Masarone M
AD  - Division of Internal Medicine and Hepatology, II degrees  University of Naples, Naples, 
      Italy.
FAU - La Mura, Vincenzo
AU  - La Mura V
AD  - Division of Internal Medicine and Hepatology, II degrees  University of Naples, Naples, 
      Italy.
FAU - Mazzotti, Arianna
AU  - Mazzotti A
AD  - Unit of Metabolic Diseases and Clinical Dietetics, "Alma Mater Studiorum" 
      University of Bologna, Policlinico S. Orsola, Via Massarenti, 9, 40138, Bologna, 
      Italy.
FAU - Bruno, Alberto
AU  - Bruno A
AD  - Division of Diabetology and Metabolic Diseases, S. Giovanni Battista Hospital, 
      Turin, Italy.
FAU - Marchesini, Giulio
AU  - Marchesini G
AD  - Unit of Metabolic Diseases and Clinical Dietetics, "Alma Mater Studiorum" 
      University of Bologna, Policlinico S. Orsola, Via Massarenti, 9, 40138, Bologna, 
      Italy. giulio.marchesini@unibo.it.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110515
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
SB  - IM
EIN - Acta Diabetol. 2017 Jul 29;:. PMID: 28756473
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Hepacivirus/genetics/isolation & purification/physiology
MH  - Hepatitis B/complications/diagnosis/*epidemiology/virology
MH  - Hepatitis B virus/genetics/isolation & purification/physiology
MH  - Hepatitis C/complications/diagnosis/*epidemiology/virology
MH  - Humans
MH  - Italy/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2011/05/17 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/03/28 00:00 [received]
PHST- 2011/04/28 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 10.1007/s00592-011-0293-x [pii]
AID - 10.1007/s00592-011-0293-x [doi]
PST - ppublish
SO  - Acta Diabetol. 2011 Dec;48(4):337-343. doi: 10.1007/s00592-011-0293-x. Epub 2011 
      May 15.