PMID- 21574753
OWN - NLM
STAT- MEDLINE
DCOM- 20120628
LR  - 20200131
IS  - 1802-9973 (Electronic)
IS  - 0862-8408 (Linking)
VI  - 60
IP  - 4
DP  - 2011
TI  - Exercise training enhances flow-mediated dilation in spontaneously hypertensive 
      rats.
PG  - 589-97
AB  - This study investigated the effect of exercise training on the flow-mediated 
      dilation (FMD) in gastrocnemius muscle arteries from spontaneously hypertensive 
      rats (SHR). SHR and WKY rats were divided into sedentary and exercised groups. 
      After swimming exercise for eight weeks, the isolated arteries were mounted on 
      pressurized myograph and FMD responses examined. The role of nitric oxide (NO), 
      prostaglandins (PGs) and endothelium derived hyperpolarizing factor (EDHF) on FMD 
      were assessed by obtaining dilation responses in the presence and absence of 
      pharmacological antagonists. N(omega)-nitro-L-arginine methyl ester (L-NAME), 
      indomethacin (INDO) and tetraethylamonium (TEA) were used to inhibit nitric oxide 
      synthase, cyclooxygenase and EDHF-mediated responses, respectively. The FMD 
      response was significantly blunted in arteries of SHR compared with WKY rats, 
      and, improved by exercise training in SHR (SHR-ET) group. In SHR arteries, L NAME 
      and TEA did not affect dilation responses to flow, while INDO led to a 
      significant enhancement in this response. Although dilation response was not 
      altered by L-NAME in arteries obtained from trained SHR, TEA caused a significant 
      attenuation and INDO led to significant increases. These results demonstrate that 
      exercise training improves FMD in SHR, and, this enhancement induced by exercise 
      training occurs through EDHF-mediated mechanism(s).
FAU - Gunduz, F
AU  - Gunduz F
AD  - Akdeniz University, Medical Faculty, Department of Physiology, Antalya, Turkey. 
      fgunduz@akdeniz.edu.tr
FAU - Kocer, G
AU  - Kocer G
FAU - Ulker, S
AU  - Ulker S
FAU - Meiselman, H J
AU  - Meiselman HJ
FAU - Baskurt, O K
AU  - Baskurt OK
FAU - Senturk, U K
AU  - Senturk UK
LA  - eng
GR  - HL 70595/HL/NHLBI NIH HHS/United States
GR  - HL15722/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110516
PL  - Czech Republic
TA  - Physiol Res
JT  - Physiological research
JID - 9112413
SB  - IM
MH  - Animals
MH  - Blood Flow Velocity/*physiology
MH  - Hypertension/*physiopathology/therapy
MH  - Male
MH  - Muscle, Skeletal/blood supply/physiology
MH  - Physical Conditioning, Animal/*methods/*physiology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Vasodilation/*physiology
EDAT- 2011/05/18 06:00
MHDA- 2012/06/29 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2012/06/29 06:00 [medline]
AID - 932166 [pii]
AID - 10.33549/physiolres.932166 [doi]
PST - ppublish
SO  - Physiol Res. 2011;60(4):589-97. doi: 10.33549/physiolres.932166. Epub 2011 May 
      16.