PMID- 21575595
OWN - NLM
STAT- MEDLINE
DCOM- 20110808
LR  - 20110606
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 409
IP  - 2
DP  - 2011 Jun 3
TI  - Caloric restriction improves efficiency and capacity of the mitochondrial 
      electron transport chain in Saccharomyces cerevisiae.
PG  - 308-14
LID - 10.1016/j.bbrc.2011.05.008 [doi]
AB  - Caloric restriction (CR) is known to extend lifespan in a variety of species; 
      however, the mechanism remains unclear. In this study, we found that CR 
      potentiated the mitochondrial electron transport chain (ETC) at both the 
      transcriptional and translational levels. Indeed, mitochondrial membrane 
      potential (MMP) was increased by CR, and, regardless of ages, overall reactive 
      oxygen species (ROS) generation was decreased by CR. With these changes, overall 
      growth rate of cells was maintained under various CR conditions, just like cells 
      under a non-restricted condition. All of these data support increased efficiency 
      and capacity of the ETC by CR, and this change might lead to extension of 
      lifespan.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Choi, Joon-Seok
AU  - Choi JS
AD  - College of Life Sciences and Biotechnology, Korea University, Seoul 136-701, 
      South Korea.
FAU - Choi, Kyung-Mi
AU  - Choi KM
FAU - Lee, Cheol-Koo
AU  - Lee CK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110507
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Electron Transport Chain Complex Proteins)
SB  - IM
MH  - *Caloric Restriction
MH  - Electron Transport Chain Complex Proteins/genetics/*metabolism
MH  - *Longevity
MH  - Membrane Potential, Mitochondrial
MH  - Mitochondria/enzymology/*physiology
MH  - Saccharomyces cerevisiae/enzymology/*physiology
MH  - Transcription, Genetic
EDAT- 2011/05/18 06:00
MHDA- 2011/08/09 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/04/29 00:00 [received]
PHST- 2011/05/01 00:00 [accepted]
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/08/09 06:00 [medline]
AID - S0006-291X(11)00761-3 [pii]
AID - 10.1016/j.bbrc.2011.05.008 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2011 Jun 3;409(2):308-14. doi: 
      10.1016/j.bbrc.2011.05.008. Epub 2011 May 7.