PMID- 21577214
OWN - NLM
STAT- MEDLINE
DCOM- 20121107
LR  - 20120523
IS  - 1476-5578 (Electronic)
IS  - 1359-4184 (Linking)
VI  - 17
IP  - 6
DP  - 2012 Jun
TI  - BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual 
      anterior cingulate cortex volume in healthy subjects.
PG  - 597-603
LID - 10.1038/mp.2011.51 [doi]
AB  - According to the neurotrophic hypothesis of depression, stress can lead to brain 
      atrophy by modifying brain-derived neurotrophic factor (BDNF) levels. Given that 
      BDNF secretion is affected by a common polymorphism (rs6265, Val66Met), which 
      also is associated with depression, we investigated whether this polymorphism 
      modifies the effect of childhood adversity (CA) on local gray matter (GM) volume 
      in depression-relevant brain regions, using data from two large cohorts of 
      healthy subjects. We included 568 healthy volunteers (aged 18-50 years, 63% 
      female) in our study, for whom complete data were available, with magnetic 
      resonance imaging data at 1.5 Tesla (N=275) or 3 Tesla (N=293). We used a whole 
      brain optimized voxel-based morphometry (VBM) approach assessing 
      genotype-dependent GM differences, with focus on the amygdala, hippocampus and 
      medial prefrontal cortex (PFC; including anterior cingulate cortex (ACC) and 
      orbitomedial PFC). CA was assessed using a validated questionnaire. In both 
      cohorts, we found that BDNF methionine (Met)-allele carriers with a history of CA 
      had significantly less GM in subgenual ACC (P<0.05) compared with Met-allele 
      carriers without CA and Val/Val homozygotes with CA. No differences were found in 
      hippocampus, amygdala and orbitomedial PFC. On the basis of our findings, we 
      conclude that BDNF Met-allele carriers are particularly sensitive to CA. Given 
      the key role of the subgenual ACC in emotion regulation, this finding provides an 
      important mechanistic link between stress and BDNF on one hand and mood 
      impairments on the other hand.
FAU - Gerritsen, L
AU  - Gerritsen L
AD  - Department of Cognitive Neuroimaging, Donders Institute for Brain, Cognition and 
      Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands. 
      l.gerritsen@donders.ru.nl
FAU - Tendolkar, I
AU  - Tendolkar I
FAU - Franke, B
AU  - Franke B
FAU - Vasquez, A A
AU  - Vasquez AA
FAU - Kooijman, S
AU  - Kooijman S
FAU - Buitelaar, J
AU  - Buitelaar J
FAU - Fernandez, G
AU  - Fernandez G
FAU - Rijpkema, M
AU  - Rijpkema M
LA  - eng
PT  - Journal Article
DEP - 20110517
PL  - England
TA  - Mol Psychiatry
JT  - Molecular psychiatry
JID - 9607835
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Atrophy/genetics
MH  - Brain Mapping/methods/*psychology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genotype
MH  - Gyrus Cinguli/*pathology
MH  - Humans
MH  - Magnetic Resonance Imaging/methods/psychology
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers, Unmyelinated/pathology
MH  - *Polymorphism, Single Nucleotide
MH  - Self Report
MH  - Stress, Psychological/*genetics/*pathology
EDAT- 2011/05/18 06:00
MHDA- 2012/11/08 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2012/11/08 06:00 [medline]
AID - mp201151 [pii]
AID - 10.1038/mp.2011.51 [doi]
PST - ppublish
SO  - Mol Psychiatry. 2012 Jun;17(6):597-603. doi: 10.1038/mp.2011.51. Epub 2011 May 
      17.