PMID- 21577296
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2150-5349 (Electronic)
IS  - 2150-5349 (Print)
IS  - 2150-5349 (Linking)
VI  - 1
IP  - 2
DP  - 2010 Apr 6
TI  - Role of proton pump inhibitors in the management of peptic ulcer bleeding.
PG  - 51-3
LID - 10.4292/wjgpt.v1.i2.51 [doi]
AB  - Peptic ulcer bleeding is a serious medical problem with significant morbidity and 
      mortality. Endoscopic therapy significantly reduces further bleeding, surgery and 
      mortality in patients with bleeding peptic ulcers and is now recommended as the 
      first hemostatic modality for these patients. The efficacy of large-dose proton 
      pump inhibitor (PPI) therapy in reducing re-bleeding after endoscopic therapy has 
      been supported by evidence derived from randomized controlled trials. It may be 
      premature to recommend small-dose intravenous injection PPI after endoscopic 
      hemostasis in patients with bleeding ulcers. An updated systematic review shows 
      that PPI therapy before endoscopy significantly reduces the proportion with major 
      stigmata and requirement for endoscopic therapy at index endoscopy. Some studies 
      show that there is no significant difference between oral and intravenous PPIs in 
      raising intragastric pH. However, clinical data is lacking in patients with 
      peptic ulcer bleeding to date.
FAU - Lin, Hwai-Jeng
AU  - Lin HJ
AD  - Hwai-Jeng Lin, Department of Medicine, Division of Gastroenterology, Changhua 
      Christian Hospital, 135 Nanhsiao Street, Changhua 500, Taiwan, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Gastrointest Pharmacol Ther
JT  - World journal of gastrointestinal pharmacology and therapeutics
JID - 101547456
PMC - PMC3091149
OTO - NOTNLM
OT  - Endoscopic therapy
OT  - Hemostasis
OT  - Peptic ulcer bleeding
OT  - Proton pump inhibitor
OT  - Re-bleeding
EDAT- 2011/05/18 06:00
MHDA- 2011/05/18 06:01
PMCR- 2010/04/06
CRDT- 2011/05/18 06:00
PHST- 2010/01/07 00:00 [received]
PHST- 2010/01/27 00:00 [revised]
PHST- 2010/02/03 00:00 [accepted]
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/05/18 06:01 [medline]
PHST- 2010/04/06 00:00 [pmc-release]
AID - 10.4292/wjgpt.v1.i2.51 [doi]
PST - ppublish
SO  - World J Gastrointest Pharmacol Ther. 2010 Apr 6;1(2):51-3. doi: 
      10.4292/wjgpt.v1.i2.51.