PMID- 21577328
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20211203
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 4
IP  - 4
DP  - 2011 Apr
TI  - Multicentric hepatic EBV-associated smooth muscle tumors in an AIDS patient: a 
      case report, investigation of mTOR activation and review of the literature.
PG  - 421-9
AB  - Epstein-Barr virus (EBV) - associated smooth muscle tumors (EBV-SMT) are a rare, 
      recently recognized distinct group of mesenchymal tumors that develop exclusively 
      in patients with immunosuppression. It is believed that tumorigenesis is, at 
      least in part, through the activation of the Akt/mammalian target of rapamycin 
      (mTOR) signal pathway. We describe the clinicopathologic and immunohistochemical 
      features of a multifocal hepatic EBV-SMT in a 34-year-old acquired 
      immunodeficiency syndrome (AIDS) patient and investigate the activation status of 
      the mTOR signal pathway in this tumor. In addition, we provide a review of the 
      literature on the clinicopathologic findings of hepatic EBV-SMT in adult AIDS 
      patients, and discuss their biologies and possible therapeutic strategies.
FAU - Shen, Qi
AU  - Shen Q
AD  - Department of Pathology and Laboratory Medicine, the University of Texas Medical 
      School at Houston, Houston TX,USA.
FAU - Feng, Wei
AU  - Feng W
FAU - Long, Michael S
AU  - Long MS
FAU - Duan, Xiuzhen
AU  - Duan X
FAU - Jaijakul, Siraya
AU  - Jaijakul S
FAU - Arias, Cesar A
AU  - Arias CA
FAU - Brown, Robert E
AU  - Brown RE
FAU - Zhao, Bihong
AU  - Zhao B
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20110423
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Antiviral Agents)
RN  - 0 (Epstein-Barr virus encoded RNA 1)
RN  - 0 (RNA, Viral)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*complications/drug 
      therapy/immunology/virology
MH  - Adult
MH  - Antiretroviral Therapy, Highly Active
MH  - Antiviral Agents/therapeutic use
MH  - Biopsy
MH  - Epstein-Barr Virus Infections/*complications/diagnosis/immunology
MH  - HIV-1/genetics
MH  - Herpesvirus 4, Human/genetics
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Liver Neoplasms/diagnosis/immunology/metabolism/*virology
MH  - Male
MH  - RNA, Viral/analysis/blood/genetics
MH  - Signal Transduction
MH  - Smooth Muscle Tumor/diagnosis/immunology/metabolism/*virology
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Tomography, X-Ray Computed
PMC - PMC3093067
OTO - NOTNLM
OT  - Epstein-Barr virus
OT  - HIV infection
OT  - Smooth muscle tumor
OT  - acquired immunodeficiency syndrome
OT  - adult
OT  - liver
EDAT- 2011/05/18 06:00
MHDA- 2011/08/17 06:00
PMCR- 2011/04/23
CRDT- 2011/05/18 06:00
PHST- 2011/04/10 00:00 [received]
PHST- 2011/04/19 00:00 [accepted]
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
PHST- 2011/04/23 00:00 [pmc-release]
PST - ppublish
SO  - Int J Clin Exp Pathol. 2011 Apr;4(4):421-9. Epub 2011 Apr 23.