PMID- 21584738 OWN - NLM STAT- MEDLINE DCOM- 20120719 LR - 20211020 IS - 1590-3478 (Electronic) IS - 1590-1874 (Linking) VI - 33 IP - 1 DP - 2012 Feb TI - Memantine effects on behaviour in moderately severe to severe Alzheimer's disease: a post-marketing surveillance study. PG - 23-31 LID - 10.1007/s10072-011-0618-0 [doi] AB - The aim of this study is to evaluate memantine effectiveness on behavioural and psychological symptoms of dementia (BPSD) in clinical practice and to identify variables that may predict the therapy effects. The effects of memantine on behaviour were analysed in the database of a post-marketing surveillance study promoted by the Lombardy Region Health Office and involving 43 Alzheimer's disease (AD) Units. From July to December 2005, 399 moderately severe-to-severe AD patients free of cholinergic medications were enrolled, treated with memantine and followed-up for 6 months. BPSD were assessed in a subgroup of 297 patients [mean age 77 +/- 8 years; 73% females; mean neuropsychiatric inventory (NPI) score 28 +/- 24] for whom the 12-item NPI subscores at baseline, and at 3 and 6 months were available. The 12 BPSD were clustered as follows: affect, physical behaviour, psychosis and hypomania. The main outcome measure was the proportion of individual cluster responders at 6 months of therapy. The proportion of individual cluster responders was 30% affect, 24% physical behaviour, 29% psychosis, 27% hypomania. Patients taking 20 mg memantine daily during the study period had a statistically significant higher probability to experience behavioural improvement than those who discontinued treatment or did not complete memantine titration (affect OR 9.0; 95% CI 3.8-21.6; physical behaviour OR 17.8; 95% CI 5.9-53.6; psychosis OR 23.6; 95% CI 5.1-110.8). The logistic regression analysis was not applicable to the hypomania subsyndrome because of the low cluster prevalence. The standard 20 mg daily memantine treatment regimen was found to be associated with a modest 6-month behavioural improvement in the affect, physical behaviour and psychosis domains in 24-30% of patients. FAU - Clerici, Francesca AU - Clerici F AD - Centre for Research and Treatment on Cognitive Dysfunctions, Chair of Neurology, University of Milan, Luigi Sacco Hospital, Via G.B. Grassi, 74, 20157 Milan, Italy. francesca.clerici1@unimi.it FAU - Vanacore, Nicola AU - Vanacore N FAU - Elia, Antonietta AU - Elia A FAU - Spila-Alegiani, Stefania AU - Spila-Alegiani S FAU - Pomati, Simone AU - Pomati S FAU - Da Cas, Roberto AU - Da Cas R FAU - Raschetti, Roberto AU - Raschetti R FAU - Mariani, Claudio AU - Mariani C CN - Memantine Lombardy Study Group LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20110517 PL - Italy TA - Neurol Sci JT - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JID - 100959175 RN - 0 (Dopamine Agents) RN - W8O17SJF3T (Memantine) SB - IM MH - Aged MH - Aged, 80 and over MH - Alzheimer Disease/*drug therapy/psychology MH - Anxiety/drug therapy/psychology MH - Apathy/drug effects MH - Depression/drug therapy/psychology MH - Dopamine Agents/administration & dosage/*therapeutic use MH - Feeding Behavior/drug effects MH - Female MH - Follow-Up Studies MH - Hallucinations/drug therapy/psychology MH - Humans MH - Male MH - Memantine/administration & dosage/*therapeutic use MH - Neuropsychological Tests MH - Product Surveillance, Postmarketing MH - Severity of Illness Index MH - Treatment Outcome FIR - Altavilla, R IR - Altavilla R FIR - Appollonio, I IR - Appollonio I FIR - Isella, V IR - Isella V FIR - Avanzi, S IR - Avanzi S FIR - Bargnani, C IR - Bargnani C FIR - Bascelli, C IR - Bascelli C FIR - Bellelli, G IR - Bellelli G FIR - Guerini, F IR - Guerini F FIR - Belotti, G IR - Belotti G FIR - Bottini, G IR - Bottini G FIR - Gerini, M IR - Gerini M FIR - Cheldi, A IR - Cheldi A FIR - Bellotti, M IR - Bellotti M FIR - Chia, F IR - Chia F FIR - Cislaghi, G IR - Cislaghi G FIR - Cusi, C IR - Cusi C FIR - Mesina, M IR - Mesina M FIR - Cuzzoni, G IR - Cuzzoni G FIR - Farina, E IR - Farina E FIR - Alberoni, M IR - Alberoni M FIR - Franceschi, M IR - Franceschi M FIR - Zucchi, M IR - Zucchi M FIR - Guerini, M IR - Guerini M FIR - Iori, T IR - Iori T FIR - Lanza, E IR - Lanza E FIR - Finotti, M IR - Finotti M FIR - Lucchelli, F IR - Lucchelli F FIR - Maggiore, L IR - Maggiore L FIR - Ratti, P L IR - Ratti PL FIR - Magnani, G IR - Magnani G FIR - Schiatti, E IR - Schiatti E FIR - Marcone, A IR - Marcone A FIR - Giusti, M C IR - Giusti MC FIR - Margarito, F P IR - Margarito FP FIR - Martina, A IR - Martina A FIR - Mauri, M IR - Mauri M FIR - Merlo, P IR - Merlo P FIR - Mazza, S IR - Mazza S FIR - Moleri, M IR - Moleri M FIR - Riva, R IR - Riva R FIR - Montecalvo, G IR - Montecalvo G FIR - Chinaglia, C Negri IR - Chinaglia CN FIR - Engaddi, I IR - Engaddi I FIR - Perini, M IR - Perini M FIR - Carnicelli, A IR - Carnicelli A FIR - Petro, E IR - Petro E FIR - Pettenati, C IR - Pettenati C FIR - Perotta, D IR - Perotta D FIR - Ranzenigo, A IR - Ranzenigo A FIR - Bertozzi, B IR - Bertozzi B FIR - Redaelli, L IR - Redaelli L FIR - Reverberi, F IR - Reverberi F FIR - Salvi, G P IR - Salvi GP FIR - Manzoni, L IR - Manzoni L FIR - Saviotti, F M IR - Saviotti FM FIR - Scarpini, E IR - Scarpini E FIR - Sinforiani, E IR - Sinforiani E FIR - Zucchella, C IR - Zucchella C FIR - Tagliavini, F IR - Tagliavini F FIR - Marcon, G IR - Marcon G FIR - Turla, M IR - Turla M FIR - Viti, N IR - Viti N FIR - Zanetti, O IR - Zanetti O FIR - Alberici, A IR - Alberici A EDAT- 2011/05/18 06:00 MHDA- 2012/07/20 06:00 CRDT- 2011/05/18 06:00 PHST- 2011/02/19 00:00 [received] PHST- 2011/04/28 00:00 [accepted] PHST- 2011/05/18 06:00 [entrez] PHST- 2011/05/18 06:00 [pubmed] PHST- 2012/07/20 06:00 [medline] AID - 10.1007/s10072-011-0618-0 [doi] PST - ppublish SO - Neurol Sci. 2012 Feb;33(1):23-31. doi: 10.1007/s10072-011-0618-0. Epub 2011 May 17.