PMID- 21587080
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20111024
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Linking)
VI  - 53
IP  - 5
DP  - 2011 Nov
TI  - Immunogenicity of hepatitis A vaccine in children with celiac disease.
PG  - 532-5
LID - 10.1097/MPG.0b013e318223b3ed [doi]
AB  - OBJECTIVES: The response to hepatitis A vaccine has not been studied in children 
      with celiac disease (CD). The aim of the present study was to evaluate the 
      immunogenicity of an inactivated hepatitis A virus (HAV) vaccine and the effect 
      of the human leukocyte antigen (HLA) type on immunogenicity in children with CD. 
      PATIENTS AND METHODS: Thirty-three patients with CD and 62 healthy controls were 
      enrolled in the study. Inactivated HAV vaccine (Havrix; GlaxoSmithKline 
      Biologicals, Rixensart, Belgium) containing 720 enzyme-linked immunosorbent assay 
      units of alum-adsorbed hepatitis A antigen was administered intramuscularly in a 
      2-dose schedule at 0 and 6 months. Seroconversion rates and antibody titers of 
      HAV were measured at 1 and 7 months. RESULTS: At 1 month, seroconversion rates 
      were 78.8% and 77.4% and geometric mean titers were 50.7 and 49.9 mIU/mL in the 
      CD and control groups, respectively (P > 0.05). At 7 months, seroconversion rates 
      were 97% and 98.4% and geometric mean titers were 138.5 and 133 mIU/mL in the CD 
      and control groups, respectively (P > 0.05). The most frequent HLA types were 
      HLA-DQ2, -DR3, and -DR7 alleles in patients with CD and HLA-DQ3, -DQ6, -DR11, and 
      -DR14 in the controls. There was no association between HLA alleles and antibody 
      titers of hepatitis A vaccine. CONCLUSION: Children with CD have a good immune 
      response to hepatitis A vaccine, similar to healthy controls.
FAU - Sari, Sinan
AU  - Sari S
AD  - Department of Pediatric Gastroenterology, Gazi University Faculty of Medicine, 
      Ankara, Turkey. drsinansari@yahoo.com
FAU - Dalgic, Buket
AU  - Dalgic B
FAU - Basturk, Bilkay
AU  - Basturk B
FAU - Gonen, Sevim
AU  - Gonen S
FAU - Soylemezoglu, Oguz
AU  - Soylemezoglu O
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - 0 (HLA Antigens)
RN  - 0 (Hepatitis A Antibodies)
RN  - 0 (Hepatitis A Vaccines)
RN  - 0 (Vaccines, Inactivated)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Celiac Disease/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Dose-Response Relationship, Drug
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - HLA Antigens/drug effects
MH  - Hepatitis A/*prevention & control
MH  - Hepatitis A Antibodies/*blood
MH  - Hepatitis A Vaccines/administration & dosage/*immunology
MH  - Hepatitis A Virus, Human/immunology
MH  - Humans
MH  - Male
MH  - Vaccines, Inactivated/administration & dosage/immunology
EDAT- 2011/05/19 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/05/19 06:00
PHST- 2011/05/19 06:00 [entrez]
PHST- 2011/05/19 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1097/MPG.0b013e318223b3ed [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2011 Nov;53(5):532-5. doi: 
      10.1097/MPG.0b013e318223b3ed.