PMID- 21590042
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20190606
IS  - 1021-335X (Print)
IS  - 1021-335X (Linking)
VI  - 4
IP  - 2
DP  - 1997 Mar-Apr
TI  - Increased polysomy 3 and 17 detected by fluorescence in situ hybridization (FISH) 
      in oral squamous cell carcinoma.
PG  - 277-80
AB  - Numerical chromosome aberrations were studied by fluorescence in situ 
      hybridization (FISH) using pericentromeric DNA probes specific for chromosomes 3 
      and 17 in 18 oral squamous cell carcinomas (SCCs) and 3 lymph nodes as control. 
      Disomy 3 and 17 was detected in approximately 90% of control cells, and in 60.9 
      +/- 4.0% and 62.7 +/- 3.6% of SCCs, respectively. Polysomy 3 and 17 significantly 
      increased in SCCs when compared to controls. The pattern of chromosome 
      aberrations varied considerably between cases. There was no obvious relationship 
      between the degree of polysomies and clinicopathological factors such as 
      tumor-differentiation, stage of the disease and clinical outcome. Chromosome 
      aberrations by FISH did not correlate with DNA aneuploidy by flow cytometry. Our 
      results indicate that oral SCCs are more frequently associated with the increased 
      copy number of chromosomes 3 and 17 than previously thought, and that a 
      correlation between chromosome aberrations by FISH and DNA aneuploidy by flow 
      cytometry is not obvious.
FAU - Tsuji, T
AU  - Tsuji T
AD  - YAMAGUCHI UNIV,SCH MED,DEPT PATHOL,UBE,YAMAGUCHI 755,JAPAN. YAMAGUCHI UNIV,SCH 
      MED,DEPT OTOLARYNGOL,UBE,YAMAGUCHI 755,JAPAN. YAMAGUCHI PREFECTURAL CENT HOSP,DIV 
      ORAL & MAXILLOFACIAL SURG,HOFU,JAPAN.
FAU - Mimura, Y
AU  - Mimura Y
FAU - Kanekawa, A
AU  - Kanekawa A
FAU - Okafuji, M
AU  - Okafuji M
FAU - Kamata, T
AU  - Kamata T
FAU - Murakami, T
AU  - Murakami T
FAU - Sasaki, K
AU  - Sasaki K
FAU - Shinozaki, F
AU  - Shinozaki F
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 2011/05/19 06:00
PHST- 2011/05/19 06:00 [entrez]
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
AID - 10.3892/or.4.2.277 [doi]
PST - ppublish
SO  - Oncol Rep. 1997 Mar-Apr;4(2):277-80. doi: 10.3892/or.4.2.277.