PMID- 21590796
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20181201
IS  - 1552-8618 (Electronic)
IS  - 0730-7268 (Linking)
VI  - 30
IP  - 8
DP  - 2011 Aug
TI  - Application of chemical toxicity distributions to ecotoxicology data requirements 
      under REACH.
PG  - 1943-54
LID - 10.1002/etc.583 [doi]
AB  - The European Union's REACH regulation has further highlighted the lack of 
      ecotoxicological data for substances in the marketplace. The mandates under REACH 
      (registration, evaluation, authorization, and restriction of chemicals) to 
      produce data and minimize testing on vertebrates present an impetus for advanced 
      hazard assessment techniques using read-across. Research in our group has 
      recently focused on probabilistic ecotoxicological hazard assessment approaches 
      using chemical toxicity distributions (CTDs). Using available data for chemicals 
      with similar modes of action or within a chemical class may allow for selection 
      of a screening point value (SPV) for development of environmental safety values, 
      based on a probabilistic distribution of toxicity values for a specific endpoint 
      in an ecological receptor. Ecotoxicity data for acetylcholinesterase inhibitors 
      and surfactants in Daphnia magna and Pimephales promelas were gathered from 
      several data sources, including the U.S. Environmental Protection Agency's ECOTOX 
      and Pesticides Ecotoxicity databases, the peer-reviewed literature, and the Human 
      and Environmental Risk Assessment (HERA) project. Chemical toxicity distributions 
      were subsequently developed, and the first and fifth centiles were used as SPVs 
      for the development of screening-predicted no-effect concentrations (sPNECs). The 
      first and fifth centiles of these distributions were divided by an assessment 
      factor of 1,000, as recommended by REACH guidance. Use of screening values 
      created using these techniques could support the processes of data dossier 
      development and environmental exposure assessment, allowing for rigorous 
      prioritization in testing and monitoring to fill data gaps.
CI  - Copyright (c) 2011 SETAC.
FAU - Williams, E Spencer
AU  - Williams ES
AD  - Department of Environmental Science, Center for Reservoir and Aquatic Systems 
      Research, Baylor University, Waco, Texas, USA. sp_williams@baylor.edu
FAU - Berninger, Jason P
AU  - Berninger JP
FAU - Brooks, Bryan W
AU  - Brooks BW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110608
PL  - United States
TA  - Environ Toxicol Chem
JT  - Environmental toxicology and chemistry
JID - 8308958
RN  - 0 (Cholinesterase Inhibitors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Pesticides)
RN  - 0 (Surface-Active Agents)
SB  - IM
MH  - Animals
MH  - Cholinesterase Inhibitors/standards/toxicity
MH  - Cyprinidae
MH  - Daphnia
MH  - Ecotoxicology/legislation & jurisprudence/*methods
MH  - Environmental Policy
MH  - Environmental Pollutants/standards/toxicity
MH  - Environmental Pollution/legislation & jurisprudence/statistics & numerical data
MH  - European Union
MH  - Humans
MH  - Pesticides/standards/toxicity
MH  - Risk Assessment/methods
MH  - Surface-Active Agents/standards/toxicity
MH  - Toxicity Tests/*methods/standards
MH  - United States
MH  - United States Environmental Protection Agency
EDAT- 2011/05/19 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/05/19 06:00
PHST- 2011/01/01 00:00 [received]
PHST- 2011/02/02 00:00 [revised]
PHST- 2011/04/21 00:00 [accepted]
PHST- 2011/05/19 06:00 [entrez]
PHST- 2011/05/19 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1002/etc.583 [doi]
PST - ppublish
SO  - Environ Toxicol Chem. 2011 Aug;30(8):1943-54. doi: 10.1002/etc.583. Epub 2011 Jun 
      8.