PMID- 21592231
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20111017
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 25
IP  - 5
DP  - 2011 Sep-Oct
TI  - Proliferation signal inhibitors and post-transplant malignancies in heart 
      transplantation: practical clinical management questions.
PG  - E475-86
LID - 10.1111/j.1399-0012.2011.01476.x [doi]
AB  - Although malignancy is a major threat to long-term survival of heart transplant 
      (HT) recipients, clear strategies to manage immunosuppression in these patients 
      are lacking. Several lines of evidences support the hypothesis of an anticancer 
      effect of proliferation signal inhibitors (PSIs: mammalian target of rapamycin 
      [mTOR] inhibitors) in HT recipients. This property may arise from PSI's ability 
      to replace immunosuppressive therapies that promote cancer progression, such as 
      calcineurin inhibitors or azathioprine, and/or through their direct biological 
      actions in preventing tumor development and progression. Given the lack of 
      randomized studies specifically exploring these issues in the transplant setting, 
      a collaborative group reviewed current literature and personal clinical 
      experience to reach a consensus aimed to provide practical guidance for the 
      clinical conduct in HT recipients with malignancy, or at high risk of malignancy, 
      with a special focus on advice relevant to potential role of PSIs.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Epailly, E
AU  - Epailly E
AD  - Les Hopitaux Universitaires de Strasbourg, Strasbourg, France.
FAU - Albanell, J
AU  - Albanell J
FAU - Andreassen, A
AU  - Andreassen A
FAU - Bara, C
AU  - Bara C
FAU - Campistol, J M
AU  - Campistol JM
FAU - Delgado, J F
AU  - Delgado JF
FAU - Eisen, H
AU  - Eisen H
FAU - Fiane, A E
AU  - Fiane AE
FAU - Mohacsi, P
AU  - Mohacsi P
FAU - Schubert, S
AU  - Schubert S
FAU - Sebbag, L
AU  - Sebbag L
FAU - Turazza, F M
AU  - Turazza FM
FAU - Valantine, H
AU  - Valantine H
FAU - Zuckermann, A
AU  - Zuckermann A
FAU - Potena, L
AU  - Potena L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110518
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Cell Proliferation/*drug effects
MH  - Heart Diseases/*complications/surgery
MH  - Heart Transplantation/*adverse effects
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Neoplasms/*drug therapy/*etiology
MH  - *Postoperative Complications
EDAT- 2011/05/20 06:00
MHDA- 2012/02/15 06:00
CRDT- 2011/05/20 06:00
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
AID - 10.1111/j.1399-0012.2011.01476.x [doi]
PST - ppublish
SO  - Clin Transplant. 2011 Sep-Oct;25(5):E475-86. doi: 
      10.1111/j.1399-0012.2011.01476.x. Epub 2011 May 18.