PMID- 21592256
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20211020
IS  - 1365-2982 (Electronic)
IS  - 1350-1925 (Print)
IS  - 1350-1925 (Linking)
VI  - 23
IP  - 8
DP  - 2011 Aug
TI  - Diagnosis of supra-esophageal gastric reflux: correlation of oropharyngeal pH 
      with esophageal impedance monitoring for gastro-esophageal reflux.
PG  - 717-e326
LID - 10.1111/j.1365-2982.2011.01726.x [doi]
AB  - BACKGROUND: Oropharyngeal (OP) pH monitoring has been developed as a new way to 
      diagnose supra-esophageal gastric reflux (SEGR), but has not been well validated. 
      Our aim was to determine the correlation between OP pH and gastro-esophageal 
      reflux (GER) events detected by multichannel intraluminal impedance-pH (MII-pH). 
      METHODS: Fifteen patients (11 males, median age 10.8 years) with suspected GER 
      were prospectively evaluated with ambulatory 24-h OP pH monitoring (positioned at 
      the level of the uvula) and concomitant esophageal MII-pH monitoring. Potential 
      OP events were identified by the conventional pH threshold of <4 and by the 
      following alternative criteria: (i) relative pH drop >10% from 15-min baseline 
      and (ii) absolute pH drop below thresholds of <5.5, 5.0, and 4.5. The 2-min 
      window preceding each OP event was analyzed for correlation with an episode of 
      GER detected by MII-pH. KEY RESULTS: A total of 926 GER events were detected by 
      MII-pH. Application of alternative pH criteria increased the identification of 
      potential OP pH events; however, a higher proportion of OP events had no temporal 
      correlation with GER (45-81%), compared with the conventional definition of 
      pH < 4 (40%). A total of 306 full-column acid reflux episodes were detected by 
      MII-pH, of which 10 (3.3%) were also identified by OP pH monitoring. CONCLUSIONS 
      & INFERENCES: Use of extended pH criteria increased the detection of potential 
      SEGR events, but the majority of decreases in OP pH were not temporally 
      correlated with GER. Oropharyngeal pH monitoring without concurrent esophageal 
      measurements may overestimate the presence of SEGR in children.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Chiou, E
AU  - Chiou E
AD  - Center for Motility and Functional Gastrointestinal Disorders, Children's 
      Hospital Boston, 300 Longwood Avenue, Boston, MA 02155, USA.
FAU - Rosen, R
AU  - Rosen R
FAU - Jiang, H
AU  - Jiang H
FAU - Nurko, S
AU  - Nurko S
LA  - eng
GR  - T32DK007477-25/DK/NIDDK NIH HHS/United States
GR  - K24 DK082792/DK/NIDDK NIH HHS/United States
GR  - K24DK082792A/DK/NIDDK NIH HHS/United States
GR  - T32 DK007477/DK/NIDDK NIH HHS/United States
GR  - R21 DK077678-02/DK/NIDDK NIH HHS/United States
GR  - K23DK073713/DK/NIDDK NIH HHS/United States
GR  - R21DK77678-2/DK/NIDDK NIH HHS/United States
GR  - K23 DK073713-04/DK/NIDDK NIH HHS/United States
GR  - R21 DK077678/DK/NIDDK NIH HHS/United States
GR  - K23 DK073713/DK/NIDDK NIH HHS/United States
GR  - K24 DK082792-03/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110518
PL  - England
TA  - Neurogastroenterol Motil
JT  - Neurogastroenterology and motility
JID - 9432572
SB  - IM
MH  - Child
MH  - Electric Impedance
MH  - *Esophageal pH Monitoring
MH  - Gastroesophageal Reflux/*diagnosis
MH  - Humans
MH  - *Hydrogen-Ion Concentration
MH  - Male
MH  - *Oropharynx
MH  - Posture
MH  - Prospective Studies
PMC - PMC3139023
MID - NIHMS291005
EDAT- 2011/05/20 06:00
MHDA- 2011/11/16 06:00
PMCR- 2012/08/01
CRDT- 2011/05/20 06:00
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
PHST- 2012/08/01 00:00 [pmc-release]
AID - 10.1111/j.1365-2982.2011.01726.x [doi]
PST - ppublish
SO  - Neurogastroenterol Motil. 2011 Aug;23(8):717-e326. doi: 
      10.1111/j.1365-2982.2011.01726.x. Epub 2011 May 18.