PMID- 21592983
OWN - NLM
STAT- MEDLINE
DCOM- 20110808
LR  - 20240317
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 203
IP  - 11
DP  - 2011 Jun 1
TI  - Human leukocyte antigen genotypes in the genetic control of adaptive immune 
      responses to smallpox vaccine.
PG  - 1546-55
LID - 10.1093/infdis/jir167 [doi]
AB  - BACKGROUND: The role of human leukocyte antigen (HLA) genes in mediating adaptive 
      immune responses to smallpox vaccine remains unknown. METHODS: We determined 
      genotypes for a group of individuals (n = 1071) who received a single dose of 
      smallpox vaccine (Dryvax, Wyeth Laboratories) and examined associations between 
      HLA alleles and 15 immune outcomes to smallpox vaccine on a per-locus and a 
      per-allele level. RESULTS: We found significant associations between the HLA-B 
      and HLA - DQB1 loci and vaccinia-induced antibodies (P = .04 for each locus), 
      with the HLA-B*1302 (P = .036), B*3802 (P = .011), DQB1*0302 (P = .015), and 
      DQB1*0604 (P = .017) alleles being associated with higher levels. Significant 
      global associations were identified between vaccinia-specific interferon (IFN)-gamma 
      and DQA1 (P = .003), interleukin (IL)-1beta and HLA-B (P = .004), tumor necrosis 
      factor (TNF)-alpha and HLA-B (P = .006), and IL-6 and HLA-B locus (P = .016) for 
      secreted cytokines, as well as between CD8alpha(+) IFN-gamma Elispot responses and DQB1 
      (P = .027). Subjects carrying B*3906 (P = .006) and B*5701 (P < .001) secreted 
      higher levels of IL-1beta than did subjects who did not carry these alleles. 
      Subjects carrying the B*5301 (P = .047) and B*5601 (P = .008) alleles secreted 
      less IL-1beta, compared with subjects who did not carry these alleles. The B*3502 (P 
      = .009), B*5601 (P = .004), and B*5701 (P < .001) alleles were significantly 
      associated with variations in TNF-alpha secretion. CONCLUSIONS: These data suggest 
      that variations in antibody and cellular IFN-gamma, IL-1beta, TNF-alpha, and IL-6 immune 
      responses after receipt of smallpox vaccine are genetically controlled by HLA 
      genes or genes in close linkage disequilibrium to these alleles.
FAU - Ovsyannikova, Inna G
AU  - Ovsyannikova IG
AD  - Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA.
FAU - Vierkant, Robert A
AU  - Vierkant RA
FAU - Pankratz, V Shane
AU  - Pankratz VS
FAU - Jacobson, Robert M
AU  - Jacobson RM
FAU - Poland, Gregory A
AU  - Poland GA
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antibodies, Viral)
RN  - 0 (Cytokines)
RN  - 0 (DryVax vaccine)
RN  - 0 (HLA Antigens)
RN  - 0 (Smallpox Vaccine)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adaptive Immunity/*genetics/immunology
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Viral/blood/immunology
MH  - Cytokines/blood/*immunology/metabolism
MH  - Enzyme-Linked Immunospot Assay
MH  - Female
MH  - HLA Antigens/*genetics/immunology
MH  - Humans
MH  - Interferon-gamma/blood/immunology
MH  - Linear Models
MH  - Male
MH  - Multivariate Analysis
MH  - Smallpox Vaccine/administration & dosage/*immunology
MH  - Tumor Necrosis Factor-alpha/blood/immunology
PMC - PMC3096794
EDAT- 2011/05/20 06:00
MHDA- 2011/08/09 06:00
PMCR- 2012/06/01
CRDT- 2011/05/20 06:00
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2011/08/09 06:00 [medline]
PHST- 2012/06/01 00:00 [pmc-release]
AID - jir167 [pii]
AID - 10.1093/infdis/jir167 [doi]
PST - ppublish
SO  - J Infect Dis. 2011 Jun 1;203(11):1546-55. doi: 10.1093/infdis/jir167.