PMID- 21593086
OWN - NLM
STAT- MEDLINE
DCOM- 20111230
LR  - 20161125
IS  - 1477-111X (Electronic)
IS  - 0267-6591 (Linking)
VI  - 26
IP  - 5
DP  - 2011 Sep
TI  - Scintigraphic parameters with emphasis on perfusion appraisal in rest 
      99mTc-sestamibi SPECT in the recovery of myocardial function after thrombolytic 
      therapy in patients with ST elevation myocardial infarction (STEMI).
PG  - 394-9
LID - 10.1177/0267659111409970 [doi]
AB  - INTRODUCTION: This study was performed to determine the clinical application of 
      rest 99mTc-sestamibi in the assessment of viability and functional improvement of 
      the left ventricle (LV) myocardium in the post-thrombolytic therapy of acute 
      myocardial infarction (AMI). MATERIAL AND METHODS: In 37 patients with AMI who 
      received thrombolytic therapy, 2-dimensional (2D) echocardiography, as well as 
      the resting redistribution of 99mTc-sestamibi, was investigated, both within 1 
      week and 3-5 months after AMI. The predictive capacity of the perfusion 
      percentage for myocardial function recovery was evaluated. Also, the capacities 
      of the possible variables in the prediction of recovery of myocardial function 
      resulting from a change in LV ejection fraction (EF) were evaluated using 
      stepwise multiple regression analysis. RESULTS: Thirty-seven patients (30 men and 
      7 women; mean age: 58+/-14 years) with AMI were enrolled in the study. 
      Redistribution was observed in 35 and 50 segments of the initial and follow-up 
      scans, respectively. In addition, 146 segments with reverse redistribution (RR), 
      both in the initial scan (118 segments) and the follow-up scan (86 segments), 
      were also observed. An apparent difference in wall motion scores was seen between 
      the initial and follow-up echocardiographs (p<0.001). Furthermore, using the 
      optimal cut-off point of perfusion percentage in each image set, sensitivity as 
      well as specificity and likelihood ratio (LR) for the improvement of regional 
      wall motion after 3-5 months were defined. CONCLUSION: These data showed that 
      redistribution and reverse redistribution of 99mTc-sestamibi post thrombolytic 
      therapy can be used as a marker of viability to predict the recovery of segmental 
      wall motion abnormality (stunning), as well as the improvement of segmental 
      perfusion uptake. This study also demonstrates that the resting 99mTc-sestamibi 
      SPECT can be used for an approximate assessment of LV function status and can 
      predict the recovery of jeopardized myocardium function after thrombolytic 
      therapy.
FAU - Javadi, H
AU  - Javadi H
AD  - Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan 
      University of Medical Sciences (GUOMS), Gorgan, Iran.
FAU - Porpiranfar, M A
AU  - Porpiranfar MA
FAU - Semnani, S
AU  - Semnani S
FAU - Jallalat, S
AU  - Jallalat S
FAU - Yavari, P
AU  - Yavari P
FAU - Mogharrabi, M
AU  - Mogharrabi M
FAU - Hooman, A
AU  - Hooman A
FAU - Amini, A
AU  - Amini A
FAU - Barekat, M
AU  - Barekat M
FAU - Iranpour, D
AU  - Iranpour D
FAU - Seyedabadi, M
AU  - Seyedabadi M
FAU - Assadi, M
AU  - Assadi M
FAU - Asli, I N
AU  - Asli IN
LA  - eng
PT  - Journal Article
DEP - 20110518
PL  - England
TA  - Perfusion
JT  - Perfusion
JID - 8700166
RN  - 0 (Radiopharmaceuticals)
RN  - 971Z4W1S09 (Technetium Tc 99m Sestamibi)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography/*methods
MH  - Echocardiography/methods
MH  - Female
MH  - *Heart Ventricles/diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Myocardial Infarction/diagnostic imaging/physiopathology/therapy
MH  - Radiography
MH  - Radiopharmaceuticals/*administration & dosage
MH  - Recovery of Function
MH  - Technetium Tc 99m Sestamibi/*administration & dosage
MH  - *Thrombolytic Therapy
MH  - Ventricular Function, Left
EDAT- 2011/05/20 06:00
MHDA- 2011/12/31 06:00
CRDT- 2011/05/20 06:00
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2011/12/31 06:00 [medline]
AID - 0267659111409970 [pii]
AID - 10.1177/0267659111409970 [doi]
PST - ppublish
SO  - Perfusion. 2011 Sep;26(5):394-9. doi: 10.1177/0267659111409970. Epub 2011 May 18.