PMID- 21593644
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20191210
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Linking)
VI  - 52
IP  - 6
DP  - 2011 Jun
TI  - Agreement between patient- and physician-completed Pediatric Ulcerative Colitis 
      Activity Index scores.
PG  - 708-13
LID - 10.1097/MPG.0b013e3182099018 [doi]
AB  - OBJECTIVES: Currently validated ulcerative colitis (UC) activity measures are 
      physician based, but incorporate patient reports of symptoms. We aimed to assess 
      whether patient-completed Pediatric UC Activity Index (PUCAI) scores are 
      comparable to those of physician scores. PATIENTS AND METHODS: We performed a 
      single-center prospective study to assess agreement between patient- and 
      physician-completed PUCAI scores. Seventy patients with UC (ages 4-29) 
      representative of all of the disease activity categories (inactive, mild, 
      moderate, and severe) in the currently published physician-completed scoring 
      system were recruited. Agreement was analyzed for PUCAI scores both as continuous 
      and categorical measures. To ascertain validity, we compared both patient- and 
      physician-completed PUCAI scores with the physician global assessment and serum 
      inflammatory markers. RESULTS: Patient- and physician-completed PUCAI summary 
      scores were identical 49% of the time, were different but within the minimal 
      clinically important difference (MCID) of 20 points 48% of the time, and were at 
      or beyond the MCID only 3% of the time. In general, patients reported higher mean 
      disease severity on their questionnaires than did their physicians, with a mean 
      difference in PUCAI scores of 3 +/- 8 (95% confidence interval 2%-5%). A 
      categorical comparison of the 2 sets of questionnaires using the disease activity 
      groups demonstrated perfect agreement for 60 (86%) pairs (kappa coefficient 0.78; 
      95% confidence interval 0.65%-0.90%). Both patient- and physician-completed PUCAI 
      scores also correlated well with the physician global assessment and serum 
      inflammatory markers. CONCLUSIONS: Our data indicate strong agreement between 
      PUCAI scores obtained directly from patients and those completed by physicians. 
      Hence, a patient-based PUCAI could complement existing instruments in both 
      clinical and research settings.
FAU - Lee, Jessica J
AU  - Lee JJ
AD  - Center for Inflammatory Bowel Disease, Division of Gastroenterology and 
      Nutrition, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, 
      USA. jessica.lee@childrens.harvard.edu
FAU - Colman, Ruben J
AU  - Colman RJ
FAU - Mitchell, Paul D
AU  - Mitchell PD
FAU - Atmadja, Melissa L
AU  - Atmadja ML
FAU - Bousvaros, Athos
AU  - Bousvaros A
FAU - Lightdale, Jenifer R
AU  - Lightdale JR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - Pediatric ulcerative colitis
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Colitis, Ulcerative/*diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Physicians
MH  - Prospective Studies
MH  - *Self Report
MH  - *Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/05/20 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/05/20 06:00
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 00005176-201106000-00011 [pii]
AID - 10.1097/MPG.0b013e3182099018 [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2011 Jun;52(6):708-13. doi: 
      10.1097/MPG.0b013e3182099018.