PMID- 21593767
OWN - NLM
STAT- MEDLINE
DCOM- 20111003
LR  - 20191210
IS  - 1523-1747 (Electronic)
IS  - 0022-202X (Linking)
VI  - 131
IP  - 8
DP  - 2011 Aug
TI  - Photoprovocation in cutaneous lupus erythematosus: a multicenter study evaluating 
      a standardized protocol.
PG  - 1622-30
LID - 10.1038/jid.2011.101 [doi]
AB  - Photosensitivity is an important and distinguishing sign in various subtypes of 
      cutaneous lupus erythematosus (CLE); however, it remains poorly defined. The 
      purpose of this study was to evaluate whether standardized photoprovocation is a 
      reproducible method to assess photosensitivity in subjects with CLE. A total of 
      47 subjects with CLE (subacute cutaneous lupus erythematosus (SCLE), n=14; 
      discoid lupus erythematosus (DLE), n=20; lupus erythematosus tumidus (LET), n=13) 
      and 13 healthy volunteers underwent photoprovocation at seven European sites. Of 
      these, 22 (47%) subjects (57% SCLE, 35% DLE, and 54% LET) and none of the healthy 
      volunteers developed photoprovoked lesions according to clinical analysis. Of 
      these 22 subjects, 19 (86%) developed lesions that were histopathologically 
      confirmed as specific for lupus erythematosus (LE). In CLE subjects who developed 
      UV-induced lesions, 86% had Fitzpatrick's phototypes I or II, and the mean 
      minimal erythema dose (MED) was significantly lower compared with subjects 
      without UV-induced lesions (P=0.004). No significant differences in 
      photoprovocation results were observed between study sites. Safety parameters 
      showed no clinically meaningful differences between CLE subjects and healthy 
      volunteers after photoprovocation. In conclusion, a standardized, safe, and 
      reproducible protocol for photoprovocation using UVA and UVB radiation induced 
      skin lesions in approximately half of all CLE subjects and showed comparable 
      results across multiple sites. This method may therefore be used for future 
      diagnostic testing and clinical trials.
FAU - Kuhn, Annegret
AU  - Kuhn A
AD  - Department of Dermatology, University of Munster, Munster, Germany. 
      kuhnan@uni-muenster.de
FAU - Wozniacka, Anna
AU  - Wozniacka A
FAU - Szepietowski, Jacek C
AU  - Szepietowski JC
FAU - Glaser, Regine
AU  - Glaser R
FAU - Lehmann, Percy
AU  - Lehmann P
FAU - Haust, Merle
AU  - Haust M
FAU - Sysa-Jedrzejowska, Anna
AU  - Sysa-Jedrzejowska A
FAU - Reich, Adam
AU  - Reich A
FAU - Oke, Vilija
AU  - Oke V
FAU - Hugel, Rainer
AU  - Hugel R
FAU - Calderon, Cesar
AU  - Calderon C
FAU - de Vries, Dick E
AU  - de Vries DE
FAU - Nyberg, Filippa
AU  - Nyberg F
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20110519
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (Antimalarials)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antimalarials/therapeutic use
MH  - Diagnostic Techniques and Procedures/adverse effects/*standards
MH  - Dose-Response Relationship, Radiation
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/*diagnosis
MH  - Lupus Erythematosus, Discoid/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Photosensitivity Disorders/*diagnosis
MH  - Reproducibility of Results
MH  - Smoking
MH  - *Ultraviolet Rays
MH  - Young Adult
EDAT- 2011/05/20 06:00
MHDA- 2011/10/04 06:00
CRDT- 2011/05/20 06:00
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2011/10/04 06:00 [medline]
AID - S0022-202X(15)35360-4 [pii]
AID - 10.1038/jid.2011.101 [doi]
PST - ppublish
SO  - J Invest Dermatol. 2011 Aug;131(8):1622-30. doi: 10.1038/jid.2011.101. Epub 2011 
      May 19.